Product Details
| Product Name:
680C91 |
CAS No.:
163239-22-3 |
| Purity:
97.12% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | 680C91 |
| Description | 680C91 is a potent and selective inhibitor of TDO, and its Ki is 51 nM. |
| Cell Research | Cell lines: rat liver cells. Concentrations: 0.1 μM, 0.5 μM, 2 μM. Incubation Time: 0 min - 120 min. Method: The combined concentration of non-labelled L-tryptophan and the L-[ring-2-14C]-tryptophan used in the assays is 20 μM and is added either with or without 68OC91 at time zero. |
| Animal Research | Animal Models: Male Wistar rats. Dosages: 15 mg/kg. Administration: Oral gavage |
| In vitro | 68OC91, a potent (Ki = 51 nM) and selective TDO inhibitor, has no inhibitory activity against monoamine oxidase A and B, indoleamine 2,3-dioxygenase (EC 1.13.11.17), 5-HT uptake and 5-HT1A,5-HT1D,5-HT2A and 5-HT2c receptors at a concentration of 10 μM. 68OC91 has no effect on the binding of tryptophan to albumin in plasma and inhibited TDO competitively with respect to its substrate tryptophan. 68OC91 inhibits the catabolism of tryptophan by rat liver cells and rat liver perfused in situ.[1] |
| In vivo | Prior administration of 68OC91 inhibits the catabolism of L-[ring-2-14C]-tryptophan and a load dose of tryptophan (100 mg/kg) in vivo. Administration of 68OC91 alone significantly increases brain tryptophan, 5-HIAA and 5-HT. A load dose of tryptophan (100 mg/kg), producing increases in brain tryptophan 4-fold greater than that seen with 68OC91, does not increase brain 5-HIAA and 5-HT to levels greater than those seen with 68OC91 and produces a shorter-lasting increase in these parameters.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (209.85 mM)
|
| Keywords | inhibit | Inhibitor | tryptophan 2,3-dioxygenasetryptophan catabolismAlzheimer’s Disease | 680C91 | 680C-91 |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States