Terbinafine Hydrochloride
| Price | $2 |
| Package | 25Kg/Drum |
| Min. Order: | 25Kg/Drum |
| Supply Ability: | 1ton |
| Update Time: | 2019-10-29 |
Product Details
| Product Name: Terbinafine Hydrochloride | CAS No.: 78628-80-5 |
| Min. Order: 25Kg/Drum | Purity: 99% |
| Supply Ability: 1ton | Release date: 2019/10/29 |
Terbinafine·HCl a member of the allylamine class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis. Research has shown that Terbinafine also reduces the ability of fungal pathogens to generate reactive oxygen species, therefore it is noted as a free radical scavenger in vitro and could potentially contain anti-inflammatory activity in vivo.
Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed. Assays further demonstrated that Terbinafine also contains anti-angiogenic effects in chick embryo chorioallantoic membranes.
Terbinafine is highly active against dermatophytes, mold, other basic fungi, and some strains of yeast. It is clinically used to treat nail and skin infections, inhibiting ergosterol synthesis at the stage of squalene epoxidation (IC50 = 30 nM for C. albicans). At 90-120 µM, terbinafine exhibits anti-tumor and anti-angiogenic activity by inducing cell cycle arrest at the G0/G1 stage in COLO 205 tumor cells and human vascular endothelial cells.
1. Terbinafine is mainly effective on the dermatophyte group of fungi.
2. As a 1% cream or powder, it is used topically for superficial skin infections such as jock itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream works in about half the time required by other antifungals.
3. Oral 250-mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail infection, typically by a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in the cuticle to which topically applied treatments are unable to penetrate in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of this and may be monitored with liver function tests. Alternatives to oral administration have been studied.
4. Terbinafine hydrochloride may induce or exacerbate subacute cutaneous lupus erythematosus. Persons with lupus erythematosus should first discuss possible risks with their doctor before initiation of therapy.
Specification
Items
Specifications
Results
Appearance
White Crystalline Powder
Identification
Infared Absorption
Complies
The retention time of the major peak
in the chromatogram of the
Assay prepration corresponds to that in
the chromatogram of the standard preparation,
as obtained in the assay
complies
Specific rotation
Between -28.6°and -35.0°, measured at 20°
-32.8°
Water
not more than 0.5%
0.12%
residue on ignition
not more than 0.2%
0.11%
Heavy metals
not more than 0.001%
complies
related compounds by HPLC(Test1)
Fructose not more than 0.3% Compound
A not more than 0.3% Other individual impurity not more than 0.1%
Total impurities not more than 0.5%
Fructose: 0.03% Compound A: 0.04%
Total impurities: 0.07%
Particle size
90% less than 350 microns
complies
Limit of sulfamate and sulfate
Sulfamate ion not more than 0.10%
Sulfate ion not more than 0.10%
complies
Residual Solvent
Methylene Chloride not more than 250μg/g
not detected
Acetone not mor than 2500μg/g
Isopropanol not more than 5000μg/g
Ethanenitrile not more than 400μg/g
n-hexane not more than 290μg/g
Ethyl Acetate not more than 2500μg/g
Pyridine not more than 100μg/g
Assay
Topiramate contains not less than 98.0% and
not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis
99.80%
Conclustion
The material complies with respect to USP32
Anti-fungal, onychomycosis
Anti-tumor and anti-angiogenic
For athlete's foot,Onychomycosis, tinea, jock itch, tinea versicolor caused by fungi have a significant effect
For bronchial asthma, asthmatic bronchitis and emphysema
Packaging
Packaging Detail
0.5kgs/Al-foil bag
1.0kgs/Al-foil bag
2.0kgs/Al-foil bag
5.0 kgs/Al-foil bag
25.0 kgs/drum
or upon customers' request.
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China- Since: 2012-02-03
- Address: No. 7, No. 7, No. 1, No. 160, Qiaokou Road, Qiaokou District, Qiaokou city.