Glimepiride
| Price | $1 |
| Package | 25Kg/Drum |
| Min. Order: | 25Kg/Drum |
| Supply Ability: | 1ton |
| Update Time: | 2019-10-30 |
Product Details
| Product Name: Glimepiride | CAS No.: 93479-97-1 |
| Min. Order: 25Kg/Drum | Purity: 99% |
| Supply Ability: 1ton | Release date: 2019/10/30 |
Glimepiride is a medium- to long-acting sulfonylureaantidiabetic drug. Like all sulfonylureas, glimepiride acts as an insulin secretagogue. It lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors.
Not all secondary sufonylureas have the same risks of hypoglycemia. Glibenclamide (glyburide) is associated with an incidence of hypoglycemia of up to 20–30%, compared to as low as 2% to 4% with glimepiride. Glibenclamide also interferes with the normal homeostatic suppression of insulin secretion in reaction to hypoglycemia, whereas glimepiride does not. Also, glibenclamide diminishes glucagon secretion in reaction to hypoglycemia, whereas glimepiride does not.
Glimepiride (Glimer) is indicated to treat type 2 diabetes mellitus; its mode of action is to increase insulin production by the pancreas. It is not used for type 1 diabetes because in type 1 diabetes the pancreas is not able to produce insulin.Its use is contraindicated in patients with hypersensitivity to glimepiride or other sulfonylureas, and during pregnancy.
COA:
Test Item
Analysis Specification
Result
Description
White to off white power
white power
Identification
IR (similar to standard)
Conforms
Related substances by HPLC
Impurity A(Cis-isomer)
≤0.8%
0.13%
Impurity B
≤0.4%
0.16%
Impurity C
≤0.1%
0.05%
Impurity D
≤0.2%
0.11%
Any other impurity
≤0.1%
0.08%
Total impurity
≤0.5%
0.23%
Heavy metals
≤10ppm
<10ppm
Loss on drying
≤0.5%
0.19%
Sulphated ash
≤0.1%
0.07%
Assay(HPLC)
98.0%~102.0%
99.59%
Residual solvents
To comply the test as pre USP<467>
Complies
Conclusion
The results Conform with USP29 Standard
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China- Since: 2012-02-03
- Address: No. 7, No. 7, No. 1, No. 160, Qiaokou Road, Qiaokou District, Qiaokou city.