7-Dehydrocholesterol

Description of 7-Dehydrocholesterol from Watson Biotechnology Co., Ltd

Specifications(COA) of 7-Dehydrocholesterol CAS 434-16-2 use for Research and Development Cosmetic and Pharmaceutical Applications

7-Dehydrocholesterol (7-DHC) is a cholesterol precursor found in the skin and other tissues. It plays a crucial role in the biosynthesis of Vitamin D3 (cholecalciferol) in humans and animals. Here are some key applications and roles of 7-Dehydrocholesterol:

 1. Vitamin D Synthesis

   - Primary Role: 7-DHC is the direct precursor of Vitamin D3. When the skin is exposed to ultraviolet B (UVB) radiation from sunlight, 7-DHC is converted to previtamin D3, which is then converted to Vitamin D3.

   - Importance: Vitamin D3 is essential for calcium and phosphorus absorption, maintaining healthy bones and teeth, and supporting immune system function. It also helps prevent disorders such as rickets in children and osteomalacia in adults.

 2. Biological Marker

   - **Marker for Smith-Lemli-Opitz Syndrome (SLOS):** 7-DHC levels are significantly elevated in individuals with SLOS, a genetic disorder that affects cholesterol metabolism. Measuring 7-DHC in plasma can help diagnose and monitor this syndrome.

 3. Research and Development

   - Study of Cholesterol Biosynthesis: 7-DHC is a critical intermediate in the cholesterol biosynthetic pathway. Researchers use it to study cholesterol metabolism, regulation, and its implications in various diseases.

   - Skin and Photobiology Research: Since 7-DHC is involved in Vitamin D synthesis in the skin, it is often studied in the context of skin biology, UV exposure, photoprotection, and related fields.

 4. Cosmetic and Pharmaceutical Applications

   - Topical Applications: Some cosmetic and pharmaceutical formulations may contain 7-DHC or its derivatives to enhance Vitamin D production or for potential antioxidant benefits.

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