7-Ketocholesterol NEW
| Price | $40 | $73 | $158 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 7-Ketocholesterol | CAS No.: 566-28-9 |
| Purity: 99.46% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 7-Ketocholesterol |
| Description | 7-Ketocholesterol is a metabolite of Cholesterol |
| In vivo | 7-ketocholesterol (7KC), in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation.?7KC induces a dose-dependent loss of cell viability and an increase in apoptosis and necrosis in the endothelial cells.?A relocalization of the tight junction proteins, zonula occludens-1 (ZO-1) and claudin-5, towards the nucleus of the cells was also observed.?These effects were significantly attenuated by ET. In addition, 7KC induces marked increases in the mRNA expression of pro-inflammatory cytokines, IL-1β IL-6, IL-8, TNF-α and cyclooxygenase-2 (COX2), as well as COX2 enzymatic activity, and these were significantly reduced by ET. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : < 4.01mg (10 mM) |
| Keywords | orphan disease | Inhibitor | inhibit | HMG-CoA reductase | Endogenous Metabolite | coronary artery disease | cholesterol biosynthesis | 7-Ketocholesterol | 7Ketocholesterol | 7 Ketocholesterol |
| Related Compound Libraries | Bioactive Compound Library | Selected Plant-Sourced Compound Library | NO PAINS Compound Library | Natural Product Library for HTS | Human Endogenous Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Covalent Natural Product Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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