Oxytetracyclinehydrochloride
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | KG/T |
| Update Time: | 2019-12-20 |
Product Details
| Product Name: Oxytetracyclinehydrochloride | CAS No.: 2058-46-0 |
| EC-No.: 218-161-2 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: KG/T |
| Release date: 2019/12/20 |
heidi59
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Product Name:
Oxytetracycline hydrochloride
Synonyms:
Pharmaceutical Raw Powder Oxytetracycline Hydrochloride / Oxytetracycline HCl;hydrocyclin;liquamycininjectable;mepatar;nsc9169;5-hydroxytetracycline hydrochloride;[4s-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride;GEOMYCIN
CAS:
2058-46-0
MF:
C22H25ClN2O9
MW:
496.89
EINECS:
218-161-2
Product Categories:
Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;L - ZEPA;NeatsAntibiotics;TetracyclinesMore...Close...;1694 Pharmaceuticals&Personal Care Products;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Chemical Structure Class;-;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisSpectrum of Activity;Mechanism of Action;Pharmaceutical intermediate
Mol File:
2058-46-0.mol
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Oxytetracycline hydrochloride Chemical Properties
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Melting point
180°C
alpha
-188～-200°(D/20℃)(c=1,0.1mol/l HCl) (calculated on the dried basis)
storage temp.
0-6°C
solubility
Freely soluble in water, sparingly soluble in ethanol (96 per cent). Solutions in water become turbid on standing, owing to the precipitation of oxytetracycline.
form
crystalline
color
yellow
PH
2.0～3.0 (10g/l, 25℃)
Water Solubility
>100 g/L
λmax
360nm(H2O)(lit.)
Sensitive
Light Sensitive
Merck
14,6976
BRN
3853107
CAS DataBase Reference
2058-46-0(CAS DataBase Reference)
EPA Substance Registry System
Oxytetracycline hydrochloride (2058-46-0)
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Oxytetracycline hydrochloride Usage And Synthesis
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Chemical Properties
Yellow Crystalline Solid
Uses
Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial
Uses
Oxytetracycline hydrochloride is a salt prepared from oxytetracycline taking advantage of the basic dimethylamino group which protonates readily to form the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, oxytetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
Brand name
Terramycin (Pfizer).
General Description
Early in 1950, Finlay et al.182 reported the isolation of oxytetracycline(Terramycin) from S. rimosus. This compoundwas soon identified as a chemical analog of chlortetracycline that showed similar antibiotic properties. The structureof oxytetracycline was elucidated by Hochstein et al.183 andthis work provided the basis for the confirmation of thestructure of the other tetracyclines.
Oxytetracycline hydrochloride is a pale yellow, bitter,crystalline compound. The amphoteric base is only slightlysoluble in water and slightly soluble in alcohol. It is odorlessand stable in air but darkens on exposure to strong sunlight.The hydrochloride salt is a stable yellow powder that ismore bitter than the free base. It is much more soluble inwater, 1 g dissolving in 2 mL, and more soluble in alcoholthan the free base. Both compounds are inactivated rapidlyby alkali hydroxides and by acid solutions below pH 2. Bothforms of oxytetracycline are absorbed rapidly and equallywell from the digestive tract, so the only real advantage thefree base offers over the hydrochloride salt is that it is lessbitter. Oxytetracycline hydrochloride is also used for parenteraladministration (intravenously and intramuscularly).
Oxytetracycline hydrochloride is a pale yellow, bitter,crystalline compound. The amphoteric base is only slightlysoluble in water and slightly soluble in alcohol. It is odorlessand stable in air but darkens on exposure to strong sunlight.The hydrochloride salt is a stable yellow powder that ismore bitter than the free base. It is much more soluble inwater, 1 g dissolving in 2 mL, and more soluble in alcoholthan the free base. Both compounds are inactivated rapidlyby alkali hydroxides and by acid solutions below pH 2. Bothforms of oxytetracycline are absorbed rapidly and equallywell from the digestive tract, so the only real advantage thefree base offers over the hydrochloride salt is that it is lessbitter. Oxytetracycline hydrochloride is also used for parenteraladministration (intravenously and intramuscularly).
General Description
Odorless fluffy yellow solid or yellow powder. Bitter taste.
Air & Water Reactions
Oxytetracycline hydrochloride is hygroscopic. Water soluble. Undergoes slow hydrolysis in the presence of water. Concentrated aqueous solutions at neutral pH hydrolyze on standing.
Reactivity Profile
Oxytetracycline hydrochloride is sensitive to light. Oxytetracycline hydrochloride may be unstable at temperatures above 77° F. Oxytetracycline hydrochloride darkens on exposure to sunlight or to moist air above 194° F. Concentrated aqueous solutions at neutral pH hydrolyze on standing. Oxytetracycline hydrochloride undergoes hydrolysis in the presence of water. Oxytetracycline hydrochloride may be incompatible with alkalis.
Fire Hazard
Flash point data for Oxytetracycline hydrochloride are not available. Oxytetracycline hydrochloride is probably combustible.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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