RN486
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | 1ton |
| Update Time: | 2019-12-20 |
Product Details
| Product Name: RN486 | CAS No.: 1242156-23-5 |
| EC-No.: 200-110-4 | Min. Order: 1KG |
| Purity: 95%~99% | Supply Ability: 1ton |
| Release date: 2019/12/20 | |
| Contact email address: Flora@coreychem.com |
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RN486 Basic information
Biological activity In vitro In vivo
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Product Name:
RN486
Synonyms:
RN486/RN-486;RN468;6-Cyclopropyl-2-[3-[1,6-dihydro-1-methyl-5-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-6-oxo-3-pyridinyl]-2-(hydroxymethyl)phenyl]-8-fluoro-1(2H)-isoquinolinone;RN486 LM-2078;RN486 TFA Salt;6-Cyclopropyl-8-fluoro-2-(2-(hydroxymethyl)-3-(1-methyl-5-(5-(4-methylpiperazin-1-yl)pyridin-2;RN486;6-cyclopropyl-8-fluoro-2-(2-(hydroxyMethyl)-3-(1-Methyl-5-((5-(4-Methylpiperazin-1-yl)pyridin-2-yl)aMiNA)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)isoquiNAlin-1(2H)-one
CAS:
1242156-23-5
MF:
C35H35FN6O3
MW:
606.6892032
EINECS:
-0
Product Categories:
Inhibitors
Mol File:
1242156-23-5.mol
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RN486 Chemical Properties
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Boiling point
868.6±65.0 °C(Predicted)
density
1.378±0.06 g/cm3(Predicted)
pka
13.95±0.10(Predicted)
CAS DataBase Reference
1242156-23-5
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Safety Information
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MSDS Information
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RN486 Usage And Synthesis
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Biological activity
RN486 is an effective BTK inhibitor with an IC50 of 4 nM.
In vitro
RN486 not only potently and selectively inhibits the Btk enzyme, but also displays functional activities in human cell-based assays in multiple cell types, blocking Fcε receptor cross-linking-induced degranulation in mast cells (IC50 = 2.9 nM), Fcγ receptor engagement-mediated tumor necrosis factor α production in monocytes (IC50 = 7.0 nM), and B cell antigen receptor-induced expression of an activation marker, CD69, in B cells in whole blood (IC50 = 21.0 nM). RN486 is able to block the signaling of BCR as demonstrated by a marked inhibition of phosphorylation of both Btk and PLCγ2 in B cells. RN486 displays a selective B cell inhibitory profile in BioMAP Systems.
In vivo
RN486 displays similar functional activities in rodent models, effectively preventing type I and type III hypersensitivity responses. More importantly, RN486 produces robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis (AIA) models. In the AIA model, RN486 inhibits both joint and systemic inflammation either alone or in combination with methotrexate, reducing both paw swelling and inflammatory markers in the blood.
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RN486 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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