GNE 7915
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 20kg |
| Update Time: | 2019-12-24 |
Product Details
| Product Name: GNE 7915 | CAS No.: 1351761-44-8 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 20kg | Release date: 2019/12/24 |
Mary
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Product Name:
GNE 7915
Synonyms:
GNE 7915;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;GNE-7915, >=98%;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone
CAS:
1351761-44-8
MF:
C19H21F4N5O3
MW:
443.3953528
EINECS:
Product Categories:
api;Inhibitors
Mol File:
1351761-44-8.mol
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GNE 7915 Chemical Properties
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Boiling point
629.9±65.0 °C(Predicted)
density
1.404±0.06 g/cm3(Predicted)
pka
2.80±0.10(Predicted)
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Safety Information
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MSDS Information
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GNE 7915 Usage And Synthesis
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Uses
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]
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GNE 7915 Preparation Products And Raw materials
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Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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