ANA12
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 20kg |
| Update Time: | 2019-12-24 |
Product Details
| Product Name: ANA12 | CAS No.: 219766-25-3 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 20kg | Release date: 2019/12/24 |
Mary
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Product Name:
ANA12
Synonyms:
ANA12;N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide;N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide
CAS:
219766-25-3
MF:
C22H21N3O3S
MW:
407.48544
EINECS:
803-090-7
Product Categories:
Inhibitors;-
Mol File:
219766-25-3.mol
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ANA12 Chemical Properties
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storage temp.
2-8°C
solubility
DMSO: ≥5mg/mL at 60°C
form
powder
color
white to beige
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Safety Information
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Hazard Codes
Xn
Risk Statements
22
WGK Germany
3
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MSDS Information
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ANA12 Usage And Synthesis
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Description
ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively.
In vitro
ANA-12 binds directly and selectively to TrkB and inhibits processes downstream of TrkB without altering TrkA and TrkC functions. In nnr5 PC12-TrkB cells, ANA-12 prevents brain-derived neurotrophic factor (BDNF)-induced neurite outgrowth at concentrations as low as 10 nM. In DRG neurons, ANA-12 eliminates the effect of BDNF on increasing inward current.
In vivo
In adult C57BL6/129SveV F1s mice, ANA-12 (0.5 mg/kg, i.p.) decreases TrKB activity in the brain and reduces the anxiety- and depression-related behaviors without affecting the neuron survival. In male C57BL/6 mice, ANA-12 (0.5 mg/kg, i.p.) shows antidepressant-like effects on lipopolysaccharide-induced depression-like behavior. In male Sprague-Dawley rats, ANA-12 (3 μg/dose) blocks the effect of medial nucleus tractus solitarius (mNTS) BDNF on reducing food intake. In male wild-type mice, ANA-12 reverses ethanol intake and induces D3 receptor downregulation, but is ineffective in D3R-/- mice. In male CocSired rats, ANA-12 (0.5 mg/kg, i.p.) reverses the diminished self-administration of cocaine.
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ANA12 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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