Oxaprozin

Price	$1
Package	1KG

Product Details

Product Name: Oxaprozin	CAS No.: 21256-18-8
Min. Order: 1IU	Purity: 99%
Supply Ability: 100kg	Release date: 2019/12/25
name: Cassie181

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Product Name:

Oxaprozin

Synonyms:

4,5-Diphenyl-2-oxazolepropanoic acid, Daypro;2-Oxazolepropanoic acid, 4,5-diphenyl-;Durapro;Oxapro;4,5-Diphenyloxazole-2-propionic acid;Alvo;4,5-Diphenyl-2-oxazolepropanoicacid\Oxaprozin;Oxaprozin,4,5-Diphenyl-2-oxazolepropanoic acid, Daypro

CAS:

21256-18-8

MF:

C18H15NO3

MW:

293.32

EINECS:

244-296-1

Product Categories:

Oxazoles, Isoxazoles & Benzoxazoles;ALINIA;Carboxylic Acids;Oxazoles, Isoxazoles & Benzoxazoles;APIs;Carboxylic Acids;-

Mol File:

21256-18-8.mol

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Oxaprozin Chemical Properties

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Melting point

154 °C

Boiling point

435.17°C (rough estimate)

density

1.2278 (rough estimate)

refractive index

1.5100 (estimate)

pka

4.3(at 25℃)

form

solid

Merck

14,6924

InChIKey

OFPXSFXSNFPTHF-UHFFFAOYSA-N

CAS DataBase Reference

21256-18-8(CAS DataBase Reference)

EPA Substance Registry System

2-Oxazolepropanoic acid, 4,5-diphenyl- (21256-18-8)

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Safety Information

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Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

24/25-36/37/39-36-26

WGK Germany

3

RTECS

RP6990000

Hazard Note

Irritant

HS Code

29349990

Hazardous Substances Data

21256-18-8(Hazardous Substances Data)

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MSDS Information

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Provider

Language

Oxaprozin

English

SigmaAldrich

English

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Oxaprozin Usage And Synthesis

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Abstract

Oxaprozin, also known as Oxaprozinum, (sold under the names: Daypro, Dayrun, Duraprox) is a non-steroidal anti-inflammatory drug (NSAID),used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative.NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Taboo

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Heart disease risk. Oxaprozin belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may increase your risk of heart-related diseases, such as heart attack, heart failure, and stroke. Your risk may be higher if you’re taking it long term, at high doses, or if you already have heart problems or risk factors for heart disease, such as high blood pressure.
May cause ulcers and stomach bleeding. Oxaprozin can cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may not cause symptoms. Smoking cigarettes or drinking alcohol can make these conditions worse.
Coronary artery bypass graft surgery. Oxaprozin shouldn’t be used for pain after coronary artery bypass graft surgery. Taking it could increase your risk for a heart attack or stroke.

References

https://en.wikipedia.org/wiki/Oxaprozin
https://www.drugs.com/cdi/oxaprozin.html
http://www.healthline.com/health/oxaprozin/oral-tablet#Highlights1

Description

Oxaprozin is a non-steroidal antiinflammatory agent indicated for use in various forms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. A long T_1/2 allows once/twice daily dosing. Structurally it is somewhat unique, being a 3- substituted, rather than a 2-substituted propionic acid.

Chemical Properties

White Solid

Originator

Wyeth (United Kingdom)

Uses

Oxaprozin is an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).

Uses

antiparasitic

Definition

ChEBI: A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthrit s and rheumatoid arthritis.

Indications

Oxaprozin (Daypro) is approved for the treatment of osteoarthritis and rheumatoid arthritis. Its long halflife allows for once daily dosing.The most frequently reported adverse effects of this drug are nausea, vomiting, and dyspepsia.

Brand name

Daypro (Searle);DURAPROX.

General Description

Oxaprozin, 4,5-diphenyl-2-oxazolepropionic acid (Daypro),differs from the other members of this group in being anarylpropionic acid derivative. It shares the same propertiesand side effects of other members in this group. It is indicatedfor the short- and long-term management of OA andRA, administered as a once-daily dose of 600- to 1,200-mgdose because of its long duration of action.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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Product Details

Company Profile Introduction

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career henan chemical co