Benznidazole
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | g/kg/Ton |
| Update Time: | 2019-12-26 |
Product Details
| Product Name: Benznidazole | CAS No.: 22994-85-0 |
| Min. Order: 1g | Purity: ≥98% |
| Supply Ability: g/kg/Ton | Release date: 2019/12/26 |
| Delivery Time: Prompt | Packaging: Bottle/Durm/Bag |
| Transportation: By air/Bay Sea/Express |
Heidi 0632
Email:heidi@coreychem.com
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Benznidazole Basic information
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Product Name:
Benznidazole
Synonyms:
benznidazole;benzonidazole;n-benzyl-2-(nitroimidazol-1-yl)-acetamid;n-benzyl-2-nitro-1-imidazoleacetamide;n-benzyl-2-nitro-imidazole-1-acetamid;n-benzyl-2-nitroimidazole-1-acetamide;radanil;ro71051
CAS:
22994-85-0
MF:
C12H12N4O3
MW:
260.25
EINECS:
Product Categories:
Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Imidazoles
Mol File:
22994-85-0.mol
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Benznidazole Chemical Properties
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Melting point
189-192 °C(lit.)
density
1.35±0.1 g/cm3(Predicted)
solubility
methanol: soluble50mg/mL, clear, colorless to yellow
pka
14?+-.0.46(Predicted)
Merck
13,1085
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Safety Information
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Hazard Codes
Xi
Risk Statements
36/37/38
Safety Statements
26-36
WGK Germany
3
RTECS
NI3340000
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MSDS Information
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Provider
Language
SigmaAldrich
English
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Benznidazole Usage And Synthesis
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Uses
Benznidazole (BNZ) is traditionally used to treat Chagas disease caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, Nifurtimox and Benznidazole, are toxic and present sever e side effects.
Definition
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.
Antimicrobial activity
It exhibits antiprotozoal activity, particularly against Trypanosoma cruzi.
Pharmaceutical Applications
A synthetic 2-nitroimidazole, formulated for oral administration. Solubility in water 400 mg/L.
Pharmacokinetics
Oral bioavailability :High
Cmax 100 mg oral ：2.2–2.8 mg/L after 3–4 h
Plasma half-life：10.5–13.6 h
Volume of distribution：c. 0.56 L/kg
Plasma protein binding： c. 44%
The 2-nitro group undergoes reduction to the amine and hydrolysis to the hydroxy derivative.
Cmax 100 mg oral ：2.2–2.8 mg/L after 3–4 h
Plasma half-life：10.5–13.6 h
Volume of distribution：c. 0.56 L/kg
Plasma protein binding： c. 44%
The 2-nitro group undergoes reduction to the amine and hydrolysis to the hydroxy derivative.
Clinical Use
N-Benzyl-2-nitroimidazole-1-acetamide (Radanil, Rochagan)is a nitroimidazole derivative that is used for the treatment ofChagas disease. It is not available in the United States but isused extensively in South America. The effectiveness of benznidazoleis similar to that of nifurtimox. Therapy forAmerican trypanosomiasis with oral benznidazole requiresseveral weeks and is frequently accompanied by adverse effectssuch as peripheral neuropathy, bone marrow depression,and allergic-type reactions.
Clinical Use
Benznidazole is used in treatment of South American trypanosomiasis (Chagas disease).
Side effects
Adverse effects are more common in the elderly and include nausea, vomiting, abdominal pain, peripheral neuropathy and severe skin reactions.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
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