APHIDICOLIN
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | g/kg/Ton |
| Update Time: | 2019-12-26 |
Product Details
| Product Name: APHIDICOLIN | CAS No.: 38966-21-1 |
| EC-No.: 609-602-3 | Min. Order: 1g |
| Purity: ≥98% | Supply Ability: g/kg/Ton |
| Release date: 2019/12/26 | |
| Delivery Time: Prompt | Packaging: Bottle/Durm/Bag |
| Transportation: By air/Bay Sea/Express |
Heidi 0653
Email:heidi@coreychem.com
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APHIDICOLIN Basic information
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Product Name:
APHIDICOLIN
Synonyms:
InSolution Aphidicolin - CAS 38966-21-1 - Calbiochem;Aphidicolin - CAS 38966-21-1 - Calbiochem;(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol;APHIDICOLIN FROM CEPHALOSPORIUM APHIDICO LA;APHIDICOLIN FROM NIGROSPORA SPHAERICA;8,11a-Methano-11aH-cycloheptaanaphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-;Aphidicolin, froM Nigrospora oryzae;Aphidicolin NSC 234714 ICI 69653
CAS:
38966-21-1
MF:
C20H34O4
MW:
338.48
EINECS:
609-602-3
Product Categories:
Di-Terpenoids;antibiotic
Mol File:
38966-21-1.mol
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APHIDICOLIN Chemical Properties
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Melting point
218-220°C
alpha
D27 +12° (c = 1 in methanol)
Boiling point
394.61°C (rough estimate)
density
1.0057 (rough estimate)
vapor pressure
0.55 hPa ( 20 °C)
refractive index
1.4434 (estimate)
Fp
87℃
storage temp.
2-8°C
solubility
ethanol: soluble1mg/mL (stable at least a week at 4°C.)
pka
14.24±0.70(Predicted)
form
White solid
color
colorless
optical activity
[α]27/D +12°, c = 1 in methanol(lit.)
Water Solubility
Soluble in DMSO or methanol. Insoluble in water. Store solutions at -20°
Merck
13,734
BRN
4689958
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Safety Information
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Safety Statements
22-24
RIDADR
NA 1993 / PGIII
WGK Germany
3
RTECS
PB9185000
F
10-21
HS Code
29419090
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MSDS Information
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Provider
Language
SigmaAldrich
English
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APHIDICOLIN Usage And Synthesis
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Chemical Properties
White crystal
Uses
(+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties.
Uses
Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumour agents, vincristine and doxorubicin.
Uses
Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.
Definition
ChEBI: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positi ns 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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