Flucloxacillin
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | g/kg/Ton |
| Update Time: | 2019-12-26 |
Product Details
| Product Name: Flucloxacillin | CAS No.: 5250-39-5 |
| EC-No.: 226-051-0 | Min. Order: 1g |
| Purity: ≥98% | Supply Ability: g/kg/Ton |
| Release date: 2019/12/26 | |
| Delivery Time: Prompt | Packaging: Bottle/Durm/Bag |
| Transportation: By air/Bay Sea/Express |
Heidi 0697
Email:heidi@coreychem.com
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Flucloxacillin Basic information
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Product Name:
Flucloxacillin
Synonyms:
(2S,5R,6R)-6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]amino]-7-keto-3,3-dimethyl-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;Fluchlxacillin;FLOXACILLIN;FLUCLOXACILLIN;Flopen;Floxapen;Flucil;Flucloxcillin
CAS:
5250-39-5
MF:
C19H17ClFN3O5S
MW:
453.87
EINECS:
226-051-0
Product Categories:
API's
Mol File:
5250-39-5.mol
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Flucloxacillin Chemical Properties
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Boiling point
677.3±55.0 °C(Predicted)
density
1.59±0.1 g/cm3(Predicted)
pka
pKa 2.7 (Uncertain)
CAS DataBase Reference
5250-39-5(CAS DataBase Reference)
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Safety Information
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MSDS Information
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Flucloxacillin Usage And Synthesis
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Uses
Antibacterial.
Definition
ChEBI: A penicillin compound having a 6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido] side-chain.
Antimicrobial activity
There is complete cross-resistance with other penicillinase-stable penicillins.
Pharmacokinetics
Oral absorption: c. 80%
Cmax 250 mg (oral): 11 mg/L after 0.5–1 h
Plasma half-life: 2 h
Plasma protein binding: 95%
Absorption and distribution
It is well absorbed after oral administration and penetrates rapidly into extravascular exudates. Its high protein binding limits its diffusion, notably into the normal CSF.
Metabolism and excretion
Flucloxacillin is partly metabolized in the liver and about 10% of the plasma concentration is made up of metabolites. It is more slowly eliminated than cloxacillin. Some appears in the bile but about 50–80% of an oral dose is recovered from the urine, about 20% as metabolites.
Cmax 250 mg (oral): 11 mg/L after 0.5–1 h
Plasma half-life: 2 h
Plasma protein binding: 95%
Absorption and distribution
It is well absorbed after oral administration and penetrates rapidly into extravascular exudates. Its high protein binding limits its diffusion, notably into the normal CSF.
Metabolism and excretion
Flucloxacillin is partly metabolized in the liver and about 10% of the plasma concentration is made up of metabolites. It is more slowly eliminated than cloxacillin. Some appears in the bile but about 50–80% of an oral dose is recovered from the urine, about 20% as metabolites.
Clinical Use
Uses are those of group 3 penicillins.
Side effects
In patients treated by intravenous infusion, about 5% developed phlebitis by the first and 15% by the second day, after which the proportion rose dramatically. Side effects are otherwise those common to penicillins.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
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