Arteether

Product Name: Arteether

Synonyms: Arteether 75887-54-6;AlphaBetaArteetherC17H28O5;Alpha Beta Arteether;aArteether;(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin;Artemotil;SM-22;10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin

CAS: 75887-54-6

MF: C17H28O5

MW: 312.4

EINECS:

Product Categories: Antimalarial;Intermediates & Fine Chemicals;Pharmaceuticals;-;Chiral Reagents;Heterocycles

Mol File: 75887-54-6.mol

Arteether Structure

Arteether Chemical Properties

Melting point 80-820C

alpha D21 +154.5° (c = 1.0 in CHCl3)

storage temp. -20°C Freezer

CAS DataBase Reference 75887-54-6

Safety Information

MSDS Information

Arteether Usage And Synthesis

Description Arteether reached the market in the Netherlands as a solution in sesame oil, administered by i.m. injection, for the treatment of severe malaria infections in children and adolescents. Artheether, a sesquiterpene acetal with an endoperoxide bridge, is an ether derivative of the naturally occuring compound artemisinin, the active component of Chinese herbal remedies. As the other structural analogs of artemisinin, such as artesunate or artemether, it acts rapidly against Plasmodium, the parasite responsible for the disease, during the early blood stage of its development. It also exhibits a gametocytocidal activity against Plasmodium falciparum, reducing its potential for transmission. Because the only controlled clinical studies had been performed in children and adolescents, this new antimalarial drug was only approved for young patients. Further studies in adults treated with 150 mg i.m. artemotil, once daily for three consecutive days, indicated that the drug was efficient, rapidly acting (parasite clearance time meanly 38 h) and well tolerated. A new promising achievement in the regression of malaria is the combination of artemisinin derivatives with other long-lived antimalarials as mefloquine or pyrimethamine/sulfa.

Chemical Properties White Crystalline Solid

Originator Central Drug Research Institute (India)

Uses Derivative of Artemisinin. Antimalarial