BAY 11-7085
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 200kg |
| Update Time: | 2019-12-31 |
Product Details
| Product Name: BAY 11-7085 | CAS No.: 196309-76-9 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 200kg | Release date: 2019/12/31 |
Mary
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Product Name:
BAY 11-7085
Synonyms:
(E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE;(E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE;BAY 11-7085;(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile;BAY 117083;(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile BAY 11-7085;BAY 11-7085 - CAS 196309-76-9 - Calbiochem;BAY 117083 (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
CAS:
196309-76-9
MF:
C13H15NO2S
MW:
249.33
EINECS:
Product Categories:
Cytokine signaling;Inhibitors
Mol File:
196309-76-9.mol
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BAY 11-7085 Chemical Properties
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Melting point
80-82℃
density
1.144
Fp
200℃
storage temp.
Store at +4°C
solubility
DMSO: >25 mg/mL, soluble
form
solid
color
white
Sensitive
Light Sensitive
InChIKey
VHKZGNPOHPFPER-ONNFQVAWSA-N
CAS DataBase Reference
196309-76-9
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Safety Information
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WGK Germany
3
RTECS
UD1312500
HS Code
29309090
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MSDS Information
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Provider
Language
SigmaAldrich
English
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BAY 11-7085 Usage And Synthesis
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Uses
In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import. BAY-11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY-11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.
Biological Activity
Irreversible inhibitor of TNF- α -stimulated I κ B α phosphorylation (IC 50 ~ 10 μ M); leads to decreased NF- κ B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .
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BAY 11-7085 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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