Halobetasol propionate

 

Product Name: Halobetasol propionate

Synonyms: 21-chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate;6 alpha-fluoroclobetasol 17-propionate;(6α，11β，16β)-21-Chloro-6，9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1，4-diene-3，20-dione;BMY-30056;CGP-14458;Uiobetasol Propionate;Ultravate;Pregna-1,4-diene-3,20-dione, 21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (6-alpha,11-beta,16-beta)

CAS: 66852-54-8

MF: C25H31ClF2O5

MW: 484.96

EINECS: 686-247-0

Product Categories: Steroids;Inhibitors

Mol File: 66852-54-8.mol

Halobetasol propionate Structure

Halobetasol propionate Chemical Properties

Melting point 213-215°C

Boiling point 570.7±50.0 °C(Predicted)

density 1.31±0.1 g/cm3(Predicted)

storage temp. Refrigerator

pka 12.55±0.70(Predicted)

CAS DataBase Reference 66852-54-8(CAS DataBase Reference)

Safety Information

HS Code 2937220000

MSDS Information

Provider Language

Ulobetasol propionate English

Halobetasol propionate Usage And Synthesis

Description Halobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both antiinflammatory and antihyperplasia properties. The compound is recommended for the treatment of moderate to severe corticosteroid-responsive dermatoses and appears to be particularly effective in patients with plaque psoriasis.

Chemical Properties White Solid

Originator Ciba-Geigy (Switzerland)

Uses Anti-inflammatory; a dermatologic agent commonly used to treat psoriasis

Brand name Ultravate (Westwood-Squibb).

Halobetasol propionate Preparation Products And Raw materials

Raw materials Methanesulfonyl chloride-->Lithium chloride-->Acetylacetone