![4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide](https://img.chemicalbook.com/ProductImageEN/2020-1/Large/8e1566a6-3cf0-492e-98ee-32edec22565f.jpg)
![4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/8e1566a6-3cf0-492e-98ee-32edec22565f.jpg)
![4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/5b012ed1-bedc-43dc-a1d3-62407935f6b8.jpg)
![4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/dbcb4d19-afd4-41da-94a0-1f94c9ee989e.jpg)
4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 200kg |
| Update Time: | 2020-01-10 |
Product Details
| Product Name: 4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide | CAS No.: 289715-28-2 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 200kg | Release date: 2020/01/10 |
Mary
▼
▲
Name
4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide
Synonym
More Synonyms
▼
▲
Description
CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft.IC50 value:Target: Nampt
Related Catalog
Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt
Research Areas >> Cancer
References
[1]. Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). J. Med. Chem., 2010, 53 (24), pp 8734-87
[2]. Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.
▼
▲
Molecular Formula
C32H34ClN7O2
Molecular Weight
584.11100
Exact Mass
583.24600
PSA
86.60000
LogP
3.56580
▼
▲
Picolamine
3731-52-0
tert-butyl 4-[N...
289686-90-4
~71%
CB 300919
289715-28-2
Literature: Cancer Research Technology Limited Patent: US6699861 B1, 2004 ; Location in patent: Page column 32 ; US 6699861 B1
2-Chloro-4-amin...
95-74-9
~%
CB 300919
289715-28-2
Literature: Bavetsias; Skelton; Yafai; Mitchell; Wilson; Allan; Jackman Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3692 - 3702
N-(3-chloro-4-m...
7149-79-3
~%
CB 300919
289715-28-2
Literature: Bavetsias; Skelton; Yafai; Mitchell; Wilson; Allan; Jackman Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3692 - 3702
▼
▲
Precursor 8
Previous 1/2 Next
DownStream 0
▼
▲
4-[N-[7-chloro-3-methyl-2-(4-methyl-piperazin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(pyridin-3-ylmethyl)benzamide
CS-0523
UNII-55I8ETE76Y
4-[N-[7-chloro-3-methyl-2-(4-methyl-piperazin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide
CB 300919
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $67.00/1kg |
VIP3Y
|
Hebei Fengjia New Material Co., Ltd
|
2024-08-22 | |
| $0.00/25kg |
VIP3Y
|
Shanghai Joiny Pharmaceutical Co.,LTD
|
2024-04-30 | |
| $0.00/1kg |
VIP1Y
|
Chongqing Zhihe Biopharmaceutical Co., Ltd.
|
2024-01-05 |
China- Since: 2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
INQUIRY