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GW842166X
Price | $1 |
Package | 1g |
Min. Order: | 1g |
Supply Ability: | 1ton |
Update Time: | 2020-01-13 |
Product Details
Product Name: GW842166X | CAS No.: 666260-75-9 |
EC-No.: 200-258-5 | Min. Order: 1g |
Purity: 95-99% | Supply Ability: 1ton |
Release date: 2020/01/13 | |
contact: Mary@coreychem.com |
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Common Name
GW842166X
CAS Number
666260-75-9
Molecular Weight
449.254
Density
1.4±0.1 g/cm3
Boiling Point
N/A
Molecular Formula
C18H17Cl2F3N4O2
Melting Point
N/A
MSDS
N/A
Flash Point
N/A
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Use of GW842166X
GW842166X is a potent and selective cannabinoid receptor 2 (CB2) agonist with IC50 values of 63 and 91 nM for human and rat CB2, respectively.
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Name
2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
Synonym
More Synonyms
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Description
GW842166X is a potent and selective cannabinoid receptor 2 (CB2) agonist with IC50 values of 63 and 91 nM for human and rat CB2, respectively.
Related Catalog
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease
Target
IC50: 63 nM (human CB2), 91 nM (rat CB2)[1]
In Vitro
GW842166X shows similar potency and efficacy for rat and human recombinant CB2 receptors. It has no significant agonist activity at concentrations up to 30 µM in human and rat CB1 recombinant assays[1].
In Vivo
GW842166X has an oral ED50 of 0.1 mg/kg in the rat FCA model of inflammatory pain and shows full reversal of hyperalgesia at 0.3 mg/kg. The blood concentrations of GW842166X in experiments are 30 nM (0.03 mg/kg), 130 nM (0.1 mg/kg), and 370 nM (0.3 mg/ kg) 1 h after dosing. After dosing for 4 days in the FCA model, no statistical difference in antihyperalgesic response is observed on day 4 relative to day 1, indicating that tolerance does not occur[1].
References
[1]. Giblin GM, et al. Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007 May 31;50(11):2597-600.
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Density
1.4±0.1 g/cm3
Molecular Formula
C18H17Cl2F3N4O2
Molecular Weight
449.254
Exact Mass
448.068054
PSA
79.63000
LogP
3.48
Index of Refraction
1.571
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cc-723
UNII-VL1I6P2DZ8
2-[(2,4-Dichlorophenyl)amino]-N-(tetrahydro-2H-pyran-4-ylmethyl)-4-(trifluoromethyl)-5-pyrimidinecarboxamide
2-((2,4-dichlorphenyl)amino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)-5-pyrimidinecarboxamide
5-Pyrimidinecarboxamide, 2-[(2,4-dichlorophen
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates:
Pharmaceutical intermediates;
OLED intermediates;
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