ML314
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 1ton |
| Update Time: | 2020-01-13 |
Product Details
| Product Name: ML314 | CAS No.: 1448895-09-7 |
| EC-No.: 200-258-5 | Min. Order: 1g |
| Purity: 95-99% | Supply Ability: 1ton |
| Release date: 2020/01/13 | |
| contact: Mary@coreychem.com |
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Common Name
ML314
CAS Number
1448895-09-7
Molecular Weight
420.504
Density
1.2±0.1 g/cm3
Boiling Point
496.1±45.0 °C at 760 mmHg
Molecular Formula
C24H28N4O3
Melting Point
N/A
MSDS
N/A
Flash Point
253.8±28.7 °C
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Use of ML314
ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM); showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization.IC50 value: 1.9 uM (EC50) [1]Target: NTR1 agonistMedicinal chemistry optimization of MLS-0233108 led to ML314, the most potent molecule in this second series that exhibited full agonist behavior (100 %) on NTR1 (EC50 = 1.9 μM). ML314 showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway. Signaling mediated by β-arrestin has distinct biochemical and functional consequences that may lead to physiological advantages as described below. This probe report describes the discovery and properties of ML301 and summarizes the HTS and follow-up campaign, which identified ML314.
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Name
2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline
Synonym
More Synonyms
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Description
ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM); showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization.IC50 value: 1.9 uM (EC50) [1]Target: NTR1 agonistMedicinal chemistry optimization of MLS-0233108 led to ML314, the most potent molecule in this second series that exhibited full agonist behavior (100 %) on NTR1 (EC50 = 1.9 μM). ML314 showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway. Signaling mediated by β-arrestin has distinct biochemical and functional consequences that may lead to physiological advantages as described below. This probe report describes the discovery and properties of ML301 and summarizes the HTS and follow-up campaign, which identified ML314.
Related Catalog
Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor
Research Areas >> Neurological Disease
References
[1]. Hershberger P, et al. Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists). Probe Reports from the NIH Molecular Libraries Program
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Density
1.2±0.1 g/cm3
Boiling Point
496.1±45.0 °C at 760 mmHg
Molecular Formula
C24H28N4O3
Molecular Weight
420.504
Flash Point
253.8±28.7 °C
Exact Mass
420.216156
PSA
59.95000
LogP
2.49
Vapour Pressure
0.0±1.3 mmHg at 25°C
Index of Refraction
1.633
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Quinazoline, 2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)-1-piperazinyl]-
2-Cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)-1-piperazinyl]quinazoline
ML314
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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