Dihydrochelerythrine
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 1ton |
| Update Time: | 2020-01-15 |
Product Details
| Product Name: Dihydrochelerythrine | CAS No.: 6880-91-7 |
| EC-No.: 200-258-5 | Min. Order: 1g |
| Purity: 95-99% | Supply Ability: 1ton |
| Release date: 2020/01/15 | |
| contact: flora@coreychem.com |
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Common Name
Dihydrochelerythrine
CAS Number
6880-91-7
Molecular Weight
349.380
Density
1.3±0.1 g/cm3
Boiling Point
565.9±50.0 °C at 760 mmHg
Molecular Formula
C21H19NO4
Melting Point
N/A
MSDS
N/A
Flash Point
171.6±27.3 °C
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Use of Dihydrochelerythrine
Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal activity.IC50 value:Target: in vitro: Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner [1]. Dihydrochelerythrine appeared to be less cytotoxic since the viability of cells exposed to 20 microM dihydrochelerythrine for 24h was reduced only to 53%. A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry [2]. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively [3].
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Name
1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine
Synonym
More Synonyms
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Description
Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal activity.IC50 value:Target: in vitro: Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner [1]. Dihydrochelerythrine appeared to be less cytotoxic since the viability of cells exposed to 20 microM dihydrochelerythrine for 24h was reduced only to 53%. A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry [2]. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively [3].
Related Catalog
Signaling Pathways >> Anti-infection >> Fungal
Natural Products >> Alkaloid
Research Areas >> Infection
References
[1]. Feng G, et al. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9.
[2]. Vrba J, et al. Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells. Toxicol In Vitro. 2008 Jun;22(4):1008-17.
[3]. Tantapakul C, et al. Antibacterial compounds from Zanthoxylum rhetsa. Arch Pharm Res. 2012 Jul;35(7):1139-42.
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Density
1.3±0.1 g/cm3
Boiling Point
565.9±50.0 °C at 760 mmHg
Molecular Formula
C21H19NO4
Molecular Weight
349.380
Flash Point
171.6±27.3 °C
Exact Mass
349.131409
PSA
40.16000
LogP
4.56
Vapour Pressure
0.0±1.5 mmHg at 25°C
Index of Refraction
1.657
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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