Hederacolchiside A1
| Price | $9.8 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | 20 tons |
| Update Time: | 2020-02-07 |
Product Details
| Product Name: Hederacolchiside A1 | CAS No.: 106577-39-3 |
| Min. Order: 1KG | Purity: ＞98%HPLC |
| Supply Ability: 20 tons | Release date: 2020/02/07 |
| Delivery Time:: Prompt | Storage:: Keep away from heat， sparks and flames |
| Package:: Bottle / Drum / Bag | Port:: Shanghai， Tianjin or Qingdao |
| Transportation:: By sea， express， air，railway | No. :: Jessie |
Jessie 785
Contact: jessie@coreychem.com
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[Product Specification】
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Name
Hederacolchiside A1
Synonym
More Synonyms
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Description
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].
Related Catalog
Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target
PI3K
Akt
mTOR
In Vitro
Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher[1]. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) [1].
In Vivo
hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1]. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells[1].
References
[1]. Yan-Er Wang, et al. Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Chinese Herbal Medicines.Volume 10, Issue 2, April 2018, Pages 215-222
[2]. Kang N, et al. Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis. Molecules. 2018 Jun 13;23(6).
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Density
1.36±0.1 g/cm3 (20 ºC 760 Torr)
Boiling Point
967.2±65.0 °C at 760 mmHg
Melting Point
253-255℃ (methanol , water )
Molecular Formula
C47H76O16
Molecular Weight
897.097
Flash Point
276.2±27.8 °C
Exact Mass
896.513306
LogP
7.36
Vapour Pressure
0.0±0.6 mmHg at 25°C
Index of Refraction
1.610
Water Solubility
Insuluble (3.9E-4 g/L) (25 ºC)
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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