Taccalonolide A
| Price | $9.8 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | 20 tons |
| Update Time: | 2020-02-07 |
Product Details
| Product Name: Taccalonolide A | CAS No.: 108885-68-3 |
| Min. Order: 1KG | Purity: ＞98%HPLC |
| Supply Ability: 20 tons | Release date: 2020/02/07 |
| Delivery Time:: Prompt | Storage:: Keep away from heat， sparks and flames |
| Package:: Bottle / Drum / Bag | Port:: Shanghai， Tianjin or Qingdao |
| Transportation:: By sea， express， air，railway | No. :: Jessie |
Jessie 785
Contact: jessie@coreychem.com
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[Product Specification】
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Name
Taccalonolide A
Synonym
More Synonyms
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Description
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3].
Related Catalog
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target
microtubule[1]
References
[1]. Tinley TL, et al. Taccalonolides E and A: Plant -derived steroids with microtubule-stabilizing activity. Cancer Res. 2003 Jun 15;63(12):3211-20.
[2]. Risinger AL, et al. Taccalonolides: Novel microtubule stabilizers with clinical potential. Cancer Lett. 2010 May 1;291(1):14-9.
[3]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8.
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Density
1.4±0.1 g/cm3
Boiling Point
776.8±60.0 °C at 760 mmHg
Molecular Formula
C36H46O14
Molecular Weight
702.742
Flash Point
237.8±26.4 °C
Exact Mass
702.288757
PSA
201.56000
LogP
2.49
Vapour Pressure
0.0±6.1 mmHg at 25°C
Index of Refraction
1.590
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
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