Kavain

Name

Kavain

Synonym

More Synonyms

Description

Kavain is a class of kavalactone isolated from Piper methysticum, which has anxiolytic and sedative properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor[1].

In Vitro

Two-electrode voltage clamp technique is used to characterize the functional properties of the major anxiolytic kavalactone, Kavain at human recombinant α1β2, β2γ2L, αxβ2γ2L, α1βxγ2L and α4β2δ γ-Aminobutyric acid type A receptors (GABAARs) expressed in Xenopus oocytes. Kavain positively modulates all receptors regardless of the subunit composition, but the degree of enhancement is greater at α4β2δ than at α1β2γ2L GABAARs. The modulatory effect of Kkavain is unaffected by flumazenil, indicating that Kavain does not enhance GABAARs via the classical benzodiazepine binding site. The β3N265M point mutation which has been previously shown to profoundly decrease anaesthetic sensitivity, also diminishes Kavain-mediated potentiation[1].

References

[1]. Chua HC, et al. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism. PLoS One. 2016 Jun 22;11(6):e0157700.

Density

1.2±0.1 g/cm3

Boiling Point

432.6±45.0 °C at 760 mmHg

Melting Point

142-148ºC

Molecular Formula

C14H14O3

Molecular Weight

230.259

Flash Point

184.6±23.3 °C

Exact Mass

230.094299

PSA

35.53000

LogP

1.69

Vapour Pressure

0.0±1.0 mmHg at 25°C

Index of Refraction

1.565

Symbol

 
GHS07

Signal Word

Warning

Hazard Statements

H302

Personal Protective Equipment

dust mask type N95 (US);Eyeshields;Gloves

Hazard Codes

Xn:Harmful;

Risk Phrases

R22

RIDADR

NONH for all modes of transport

WGK Germany

3