Procaine penicilline G hydrate

Product Name: Procaine penicilline G hydrate

Synonyms: afsillin;ampin-penicillin;aquacillin;aquasuspen;avloprocil;benzylpenicillinicacidprocainesalthydrate;abbocillin-dc;crysticillin

CAS: 6130-64-9

MF: C29H40N4O7S

MW: 588.72

EINECS: 612-112-2

Product Categories: Agro-Products;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds

Mol File: 6130-64-9.mol

Procaine penicilline G hydrate Structure

Procaine penicilline G hydrate Chemical Properties

Melting point 106-110° (with decompn)

density 1.255-1.256

solubility Slightly soluble in water, sparingly soluble in ethanol (96 per cent).

form neat

CAS DataBase Reference 6130-64-9(CAS DataBase Reference)

Safety Information

Hazard Codes Xn

Risk Statements 42/43

Safety Statements 36

RTECS XH9450000

HS Code 2941102000

Toxicity LD50 s.c. in mice: 2.3 g/kg (Soehring)

MSDS Information

Provider Language

Procaine penicilline G hydrate English

Procaine penicilline G hydrate Usage And Synthesis

Chemical Properties White Solid

Uses Procaine penicilline G hydrate is a composed of the β-lactam antibiotic of Penicillin G and the sodium channel blocker Procaine. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Procaine Penicillin G is used a growth stimulant for poultry.

Brand name Duracillin(Lilly); Pfizerpen (Pfizer).

Antimicrobial activity The procaine salt of benzylpenicillin. Poorly soluble (1:200 in water). Administered intramuscularly as a suspension of crystals which slowly dissolve at the site of the injection.

It must not be given intravenously. Intramuscular administration produces a flat sustained plasma concentration of penicillin, which is much lower than that achieved by an equivalent dose of benzylpenicillin, with plasma levels still detectable 24 h later. An injection of 0.6 g yields a peak plasma concentration of 1–2 mg benzylpenicillin/L after 2–4 h. Free procaine is detectable in the plasma within 30 min.

Very severe and potentially fatal reactions resembling those of anaphylactic shock, but non-allergic in character, may occur, probably due to accidental entry into the vascular system at the site of injection and blockage of pulmonary and cerebral capillaries by crystals of the suspension. Reactions due to liberated procaine may include acute anxiety, hypertension, tachycardia, vomiting, audiovisual hallucinations and acute psychotic disturbance. The most severe reactions lead to convulsions and cardiac arrest. Other reactions are those to liberated benzylpenicillin.