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Postion:Product Catalog >Delafloxacin
Delafloxacin
  • Delafloxacin
  • Delafloxacin
  • Delafloxacin

Delafloxacin NEW

Price $15 $5 $1
Package 1kg 10kg 50kg
Min. Order: 1kg
Supply Ability: 500
Update Time: 2024-06-26

Product Details

Product Name: Delafloxacin CAS No.: 189279-58-1
Min. Order: 1kg Purity: 99.9%
Supply Ability: 500 Release date: 2024/06/26
Cas No.189279-58-1SDFDownload SDF
PubChem ID487101AppearancePowder
FormulaC18H12ClF3N4O4M.Wt440.76
Type of CompoundN/AStorageDesiccate at -20°C
SynonymsRX-3341; WQ-3034; ABT492
SolubilityDMSO: 25 mg/mL (56.72 mM)
Chemical Name1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxoquinoline-3-carboxylic acid
SMILESC1C(CN1C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4=NC(=C(C=C4F)F)N)F)O
Standard InChIKeyDYDCPNMLZGFQTM-UHFFFAOYSA-N
Standard InChIInChI=1S/C18H12ClF3N4O4/c19-12-13-7(1-9(20)14(12)25-3-6(27)4-25)15(28)8(18(29)30)5-26(13)17-11(22)2-10(21)16(23)24-17/h1-2,5-6,27H,3-4H2,(H2,23,24)(H,29,30)
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping ConditionPackaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Biological Activity of Delafloxacin
DescriptionDelafloxacin (RX-3341, ABT-492) is a fluoroquinolone antibiotic agent. IC50 Value: MICs ranging from 0.0078 to 0.125 micro g/ml for levofloxacin-resistant Streptococcus pneumoniae strains [1] Target: Antibacterial ABT-492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms. in vitro: ABT-492 exhibited excellent in vitro activities against all 326 aerobic and anaerobic antral puncture sinus isolates tested with MICs (in micrograms per milliliter) at which 90% of the isolates tested were inhibited as follows: Haemophilus influenzae, 0.001; Moraxella catarrhalis, 0.008; and Streptococcus pneumoniae, 0.015 [2]. ABT-492 was as active as trovafloxacin against Chlamydia trachomatis, indicating good intracellular penetration and antibacterial activity [3]. in vivo: Clinical trial: N/A

References:
[1]. Gunderson SM, Hayes RA, Quinn JP, In vitro pharmacodynamic activities of ABT-492, a novel quinolone, compared to those of levofloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Antimicrob Agents Chemother. 2004 Jan;48(1):203-8. [2]. Goldstein EJ, Citron DM, Merriam CV, In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis. Antimicrob Agents Chemother. 2003 Sep;47(9):3008-11. [3]. Nilius AM, Shen LL, Hensey-Rudloff D, In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone. Antimicrob Agents Chemother. 2003 Oct;47(10):3260-9.

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Company Profile Introduction

Hebei Hongtan Technology Co., Ltd. was established in 2018. In 2019, the Ministry of Foreign Trade was established. The team has 10 members and has invested $300,000 in product development. Our goal is to make everyone can use inexpensive beauty products, the company's products have passed the CE certification, the main products are slimming peptide, anti-wrinkle peptide, melanin peptide, etc., reliable quality, inexpensive.

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