![Ketoprofen](/ProductImageEN/2024-04/Large/39b87cf4-30d6-4085-8bf4-dd72762b60ba.gif)
Ketoprofen NEW
Price | $5 | $0.1 |
Package | 1KG | 1000KG |
Min. Order: | 1KG |
Supply Ability: | g-kg-tons, free sample is available |
Update Time: | 2024-04-16 |
Product Details
Product Name: Ketoprofen | CAS No.: 22071-15-4 |
Min. Order: 1KG | Purity: 99% |
Supply Ability: g-kg-tons, free sample is available | Release date: 2024/04/16 |
Lead time: In stock, ready for shipment | Packaging: bag/bottle/drum/IBC |
Delivery: By express, by air, by sea | Origin: Manufacturer, advantage product |
COA, MSDS: Available, contact us for details | Name: Tina |
1. Materials information
Name | ketoprofen |
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Synonym | More Synonyms |
Description | Ketoprofen is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively. |
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Related Catalog | Research Areas >> Inflammation/Immunology |
Target | COX-1:2 nM (IC50, in human blood monocytes) COX-2:26 nM (IC50, in human blood monocytes) |
In Vitro | Ketoprofen (Compound 2) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1]. |
In Vivo | Ketoprofen (0.32-10 mg/kg, s.c) dose-dependently inhibits acid-induced depression of nesting (IC50, 2.05 mg/kg), and reverses CFA-induced such depression at 0.1-10 mg/kg, with an IC50 of 0.18 mg/kg in mice[2]. |
Animal Admin | First, Ketoprofen (0.1-1.0 mg/kg) and morphine (0.1-1.0 mg/kg) are evaluated for their effectiveness to block U69,593-induced depression of nesting. For these studies, Ketoprofen or morphine is administered 30 min before nesting, 1.0 mg/kg U69,593 is administered 15 min before nesting, and each set of conditions is tested in a group of six mice[2]. |
References | [1]. Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7. [2]. Negus SS, et al. Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice. Pain. 2015 Jun;156(6):1153-60. |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 431.3±28.0 °C at 760 mmHg |
Melting Point | 93-96°C |
Molecular Formula | C16H14O3 |
Molecular Weight | 254.281 |
Flash Point | 228.8±20.5 °C |
Exact Mass | 254.094299 |
PSA | 54.37000 |
LogP | 2.81 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 1.592 |
ketoprofen MSDS(Chinese) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol | ![]() GHS06 |
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Signal Word | Danger |
Hazard Statements | H301-H315-H319-H335 |
Precautionary Statements | P261-P301 + P310-P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T: Toxic; |
Risk Phrases | R25;R36/37/38 |
Safety Phrases | S26-S45-S36/37/39 |
RIDADR | 2811 |
RTECS | UE7570000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
HS Code | 2916392000 |
![]() neomenthyldiphe... 216019-59-9 ![]() (3-ethenylpheny... 63444-57-5 ![]() Sulfuric acid 7664-93-9 ![]() 3-Pentanone 96-22-0 ~88% Detail |
Literature: Albemarle Corporation Patent: US6096920 A1, 2000 ; |
![]() carbon monoxide 201230-82-2 ![]() 3-ethynylbenzop... 69355-34-6 ~55% ![]() ketoprofen 22071-15-4 ![]() 3-(3-benzoylphe... 41652-24-8 |
Literature: Tetrahedron Letters, , vol. 32, # 15 p. 1769 - 1770 |
![]() (+)-α-(3-... 22161-82-6 ~86% ![]() ketoprofen 22071-15-4 |
Literature: Chen, Fener; Liu, Jidong; Shao, Lanying; Yan, Qiongjiao Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 8 p. 989 - 992 |
Precursor 8 | Previous 1/2 Next |
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DownStream 9 | Previous 1/3 Next |
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HS Code | 2918300090 |
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Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental... | |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ... | |
Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins Bioorg. Med. Chem. 17 , 896-904, (2009) This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret... |
2-(3-benzoyl-phenyl)propionic acid |
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MFCD00055790 |
racemic-Ketoprofen |
Orugesic |
Iso-K |
Oscorel |
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Oruvail |
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Toprek |
2-(3-Benzoylphenyl)propanoic acid |
Kefenid |
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Orudis |
Benzeneacetic acid, 3-benzoyl-α-methyl- |
benzeneacetic acid, 3-benzoyl-a-methyl- |
ru4733 |
EINECS 244-759-8 |
Enantyum |
(±)-Ketoprofen |
Topre |
2-(3-benzoylphenyl)propionic acid |
aneol |
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
By Express
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
By Air
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
By Sea
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
For more details, pls contact us freely.
Email address: Tina@fdachem.com
Mob: 86 13213167925
WhatsApp/Skype/Wechat/LINE: 86 13213167925
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- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro