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Postion:Product Catalog >Pharmaceutical intermediates>Bulk Drug Intermediates>Linagliptin
Linagliptin
  • Linagliptin
  • Linagliptin
  • Linagliptin
  • Linagliptin
  • Linagliptin

Linagliptin NEW

Price Get Latest Price
Package 10g/Bag 100g/Bag 1000g/Bag
Min. Order: 100g/Bag
Supply Ability: 20 tons
Update Time: 2024-10-11

Product Details

Product Name: Linagliptin CAS No.: 668270-12-0
EC-No.: 1308068-626-2 Min. Order: 100g/Bag
Purity: 99% up, High Density Supply Ability: 20 tons
Release date: 2024/10/11

Product Information 



Product name

Linagliptin

CAS No.

668270-12-0

Molecular Formula

C25H28N8O2

Molecular Weight

472.55

Quality Standard

98% up by HPLC

Appearance

Off-white to light-yellow crystalline powder



COA of Linagliptin 



ITEMS

SPECIFICATION

RESULT

Appearance

Off-white to light-yellow crystalline powder

Light yellow crystalline powder

Solubility

Soluble in methanol and sparingly soluble in 2-propanol

Conforms



Identity

(1) The infrared absorption spectrum of the sample in potassium bromide dispersion is concordant with that of a similar preparation of working standard.


Conforms

(2) The retention time of the main peak of testing solution should be confirmed with the reference solution in HPLC chromatogram.


Conforms

Melting point

200.0 C - 206.0C

203.0C - 204.5C

Loss on drying

 1.0%

0.38%

Residual solvents

Methanol  3000 ppm

Isopropanol  5000 ppm

DMF  880 ppm

Dichloromethane  600 ppm

ND

4621 ppm

ND

ND

Residual on ignition

 0.1%

0.08%

Related substance

Max single impurity  0.1%

Total impurities  1.0%

0.07%

0.21%

Heavy metals

 10 ppm

Conforms

Isomer

 0.15%

ND

Assay

98.0% - 102.0%

99.89%

Conclusion

The sample complies with the above specification



Usage 


Linagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4), which degrades incretin-like polypeptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Linagliptin increases the concentration of active incretin hormones, stimulates insulin release in a glucose-dependent manner, and reduces circulating glucagon levels.


Linagliptin in combination with metformin and sulfonylureas, with diet and exercise, can be used for glycemic control in adults with type II diabetes.


Company Information

Article illustration





Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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