Oxolinic Acid NEW

Manufacturer Provide Pharmaceutical Grade Raw Powder 99% CAS14698-29-4 Oxolinic Acid

Introduction

1.Product Name: Oxolinic Acid

2.Other Name :1-ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylicacid;1-ethyl-6,7-methylenedioxo-4-quinoline-3-carboxlicacid

3.CAS NO:14698-29-4

4.Purity: 99%min
5.Appearance:White Crystalline Powder

6.Molecular formula: C13H11NO5

7.Molecular weight:261.23

8.Melting Point :314-316°C (dec.)

9.Boiling Point :473°C

10.Density:1.3038 g/cm3

11.Storage:Keep in dark place,Sealed in dry,2-8°C

Oxolinic acid  is a quinolone antibiotic developed in Japan in the 1970s. Dosages 12-20 mg/kg  orally administered
for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake
inhibitor and has stimulant effects in mice.

Application
Oxolinic acid  belongs to the first generation of quinolones, and its mechanism of action is to inhibit the synthesis of bacterial deoxynucleotides. It has strong antibacterial effect on gram-negative bacteria, but no antibacterial effect on fungi and mycobacterium tuberculosis. The MIC50 was 0.02 ~ 0.09 g/ml. Carps were given oral infusion of 5mg/kg, 10mg/kg, 20mg/kg and 40mg/kg for a single time. After 15-24h, the blood concentration peaked, and the blood concentration maintained above 0.2 g/ml for 66h. The toxicity of this product is very small, acute toxicity test for carp oral LD50 is more than 4000mg/kg.

Indications
Oxolinic acid  has become a special drug for aquatic products.Can be used for the prevention and control of fish, red porgy, horse mackerel, tilapia, sarcoidosis, coho salmon, trout, rose boils disease, vibrio disease, bream bacterial sepsis, intestinal disease, spot fork tail intestinal type of sepsis, eel red fin disease, red dot disease, Japanese prawn vibriosis, sweet fish unit cell.