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Postion:Product Catalog >API>Hormones and the Endocrine System>Pancreatic hormone and blood sugar regulation>Repaglinide
Repaglinide
  • Repaglinide
  • Repaglinide

Repaglinide NEW

Price $8 $3 $1
Package 1KG 25KG 100KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-29

Product Details

Product Name: Repaglinide CAS No.: 135062-02-1
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/29
Lead time: In stock, ready for shipment IIn stock, r: bag/bottle/drum/IBC
bag/bottle: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MS: Available, contact us for details NAME: Sun

1. Materials information

Names

NameRepaglinide
SynonymMore Synonyms

 Repaglinide Biological Activity

DescriptionRepaglinide(AG-EE 623ZW) is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes. IC50 value:Target: Repaglinide is very rapidly absorbed (tmax less than 1 hour) with a t1/2 of less than one hour. Furthermore, repaglinide is inactivated in the liver and more than 90 % excreted via the bile. Repaglinide (1 mg/kg p.o.) was effective (P < 0.001) as an insulin-releasing agent in a rat model (low-dose streptozotocin) of type 2 diabetes.
Related Catalog
Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease
References

[1]. Marbury T, Huang WC, Strange P, Lebovitz H et al. Repaglinide versus glyburide: a one-year comparison trial. Diabetes Research and Clinical Practice .1999, 43(3):155-166.

[2]. David R. Owens . Repaglinide-prandial glucose regulator: a new class of oral antidiabetic drugs . Diabetic Medicine 1998,15 : S28-S36.

[3]. J Fuhlendorff, P Rorsman, H Kofod. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes. 1998. 47 (3): 345-351 .

[4]. R Moses, R Slobodniuk, S Boyages. Effect of repaglinide addition to metformin monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care . 22 (1 ) : 119-124 .

[5]. Julio Rosenstock, MD, David R. Hassman, DO, Robert D. Madder, DO. Diabetes Care June 2004 vol. 27 no. 6 1265-1270

[6]. Shiling Hu1, Shuya Wang1, Barbara Fanelli1. Pancreatic β-Cell KATP Channel Activity and Membrane-Binding Studies with Nateglinide: A Comparison with Sulfonylureas and Repaglinide . JPET , 2000,293 (2 ): 444-452 .

 Chemical & Physical Properties

Density1.1±0.1 g/cm3
Boiling Point672.9±55.0 °C at 760 mmHg
Melting Point129-130.2 °C
Molecular FormulaC27H36N2O4
Molecular Weight452.586
Flash Point360.8±31.5 °C
Exact Mass452.267517
PSA78.87000
LogP4.69
Vapour Pressure0.0±2.2 mmHg at 25°C
Index of Refraction1.568
Storage condition2-8°C
Water SolubilityDMSO: 34 mg/mL

 MSDS

Repaglinide MSDS(Chinese)

 Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard CodesXn
RIDADRNONH for all modes of transport
WGK Germany2
RTECS000000033825
HS Code2933399090

 Synthetic Route

Previous 1/8 Next
Article illustration

Repaglinide eth...

147770-06-7

~92%

Article illustration

Repaglinide

135062-02-1

Literature: Grell, Wolfgang; Hurnaus, Rudolf Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
Article illustration

N/A

147769-96-8

~%

Article illustration

Repaglinide

135062-02-1

Literature: Chimia, , vol. 60, # 9 p. 593 - 597
Article illustration

Piperidine

110-89-4

~%

Article illustration

Repaglinide

135062-02-1

Literature: Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5219 - 5246

 Precursor & DownStream

Precursor  5

Previous 1/2 Next

  • Article illustration CAS#:147770-06-7
    Repaglinide eth...

  • Article illustration CAS#:110-89-4
    Piperidine

  • Article illustration CAS#:72752-52-4
    1-(2-Cyanopheny...

  • Article illustration CAS#:873-32-5
    2-Chlorobenzonitrile

DownStream  0



 Customs

HS Code2933399090
Summary2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%




2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137

















Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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  • Since: 2023-02-10
  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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