Acemetacin NEW
| Price | $29 |
| Package | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Acemetacin | CAS No.: 53164-05-9 |
| Purity: 99.26% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Acemetacin |
| Description | Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin and a potent non-steroidal anti-inflammatory drug derived from indol-3-acetic acid, with its activity primarily attributed to its active metabolite, indomethacin. In clinical trials, acemetacin shows better gastric tolerability compared to indomethacin. |
| In vitro | In rats pre-treated with COX-2 and NOS inhibitors, despite significant inhibition of COX activity, Acemetacin significantly reduces gastrointestinal damage compared to Indomethacin. |
| In vivo | Acemetacin exerts its anti-inflammatory effect by inhibiting the synthesis of prostaglandins (PG). In inflamed synovial tissue, Acemetacin (10 μM) prevents the release of Prostaglandin E2 (PGE2). It inhibits the release of prostaglandin E2 in joint synovial tissues in vitro. During the incubation of gastric mucosa, the concentration-dependent inhibition of PGE accumulation by Acemetacin is not as effective as Indomethacin, and its reduction effect on gastric 6-keto-PGF1α and thromboxane B2 is also lower than that of Indomethacin. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 77 mg/mL (185.2 mM) Ethanol : 54 mg/mL (129.9 mM) |
| Keywords | inhibit | Cyclooxygenase | COX | K 708 | Inhibitor | TVX-1322 | Acemetacin | TVX1322 | K708 |
| Inhibitors Related | Ibuprofen | Acetaminophen | Diclofenac Potassium | Paradol | Indomethacin sodium hydrate |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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