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Postion:Product Catalog >API>Nervous system drugs>Antidepressants, Antimanics drugs>Agomelatine
Agomelatine
  • Agomelatine

Agomelatine NEW

Price $50
Package 1kg
Min. Order: 1kg
Supply Ability: 20 tons
Update Time: 2024-04-02

Product Details

Product Name: Agomelatine CAS No.: 138112-76-2
EC-No.: 629-727-7 Min. Order: 1kg
Purity: 99.8% Supply Ability: 20 tons
Release date: 2024/04/02

Agomelatine large stocks Cas 138112-76-2Article illustration

AGOMELATINE Usage And Synthesis
DescriptionAgomelatine is an agonist of melatonin (MT) receptors and a derivative of melatonin . It binds to MT1 and MT2 receptors (Kis = 0.14 and 0.41 nM, respectively) and has an EC50 value of 0.1 nM in a [35S]GTPγS binding assay using CHO cells expressing MT2 receptors. Agomelatine is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B and 5-HT2C (Kis = 0.26 and 0.71 nM, respectively, for the human receptors). Agomelatine (40 mg/kg) inhibits the penile erection response induced by the 5-HT2 agonist Ro 60-0175 in rats. It also increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats when administered at doses ranging from 20 to 80 mg/kg. Agomelatine (10 mg/kg) reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze in mice, indicating antidepressant-like and anxiolytic-like activity, in a transgenic neuroendocrine model of depression. It also increases the rate of readjustment to circadian activity cycles following an induced phase shift.
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Company Profile Introduction

Hubei Chuyan Biopharmaceutical Co., Ltd. is located in Wuhan, Hubei Province, China. The company is a product research and development, production, agent, sales in one of the high-tech enterprise integrating inorganic chemicals, organic chemicals, flavors and fragrances, pharmaceutical raw materials, intermediates and other fine chemical products. The company has established good cooperative relations with a number of inspection and testing institutions and large companies at home and abroad, and has a sound scientific research system and quality certification system. The company enjoys a high reputation at home and abroad in line with the business philosophy of "integrity management, quality control and customer first". The company has two pilot production bases, mainly engaged in the customized production of pharmaceutical raw materials, pharmaceutical intermediates, veterinary raw materials, in the process of production in strict compliance with ISO9001 and ISO. Our company offers variety of products which can meet your multifarious demands. We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with anirresistible force. Our company has long-term cooperation with Wuhan Research Institute and other universities, and has a sound scientific research system and quality certification system. The company has two pilot production sites, mainly engaged in the production of bulk drugs, pharmaceutical intermediates, and customized special chemicals. After several years of operation, the products are sold at home and abroad, won numerous praise. In the future business, we will continue to adhere to the principle of heavy coopera

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  • Since: 2023-08-14
  • Address: Hanjie, Wuchang, Wuhan City, Wuhan, Hubei, China
INQUIRY
Jennie
+66-84 187 1897
chuyan@chuyan.co