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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Proteases>Serine Protease Inhibitors>Alvelestat
Alvelestat
  • Alvelestat

Alvelestat NEW

Price $30 $38 $54
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Alvelestat CAS No.: 848141-11-7
Purity: 99.87% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameAlvelestat
DescriptionAlvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity.
In vitroIn a mouse model of (smoke)-induced airway inflammation, AZD9668 significantly reduced the number of (neutrophils) in the bronchoalveolar lavage (BAL) and the level of BAL IL-1β. Oral administration of AZD9668 in both mice and rats was able to inhibit (NE)-induced lung injury.
In vivoIn whole blood stimulated by yeast polysaccharide, AZD9668 effectively inhibits NE (NE) activity in the supernatant of antigen-challenged cells and on the surface of stimulated polymorphonuclear cells.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 40 mg/mL (73.32 mM)
KeywordsElastase | AZD 9668 | Inhibitor | AZD-9668 | inhibit | Alvelestat
Inhibitors RelatedPMSF | Nafamostat mesylate | Diminazene Aceturate | AEBSF hydrochloride | 2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one | Leupeptin Hemisulfate | Ceritinib | Aprotinin | Sivelestat | 4-Aminobenzamidine dihydrochloride | 2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- | Benzamidine hydrochloride
Related Compound LibrariesHighly Selective Inhibitor Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Inhibitor Library | Orally Active Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Human Metabolite Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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