Product Details
| Product Name:
AMG-1694 |
CAS No.:
1361217-07-3 |
| Purity:
97.97% |
Supply Ability:
10g |
| Release date:
2024/11/16 |
Product Introduction
Bioactivity
| 名称 | AMG-1694 |
| 描述 | AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation. |
| 体外活性 | AMG-1694 demonstrates high efficacy in reinstating the enzymatic activity of GK in the presence of GKRP with an EC50 of 0.020 μM.[1] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (93.7 mM)
|
| 关键字 | AMG-1694 | AMG 1694 | AMG1694 |
| 相关产品 | ARRY-403 | Globalagliatin | ML251 | PFK-015 | 3PO | PFKFB3-IN-2 | Oxfendazole | AZ PFKFB3 26 | PFK-158 | Dorzagliatin | (1S,2R)-Globalagliatin | PF-04937319 |
| 相关库 | 经典已知活性库 | 激酶抑制剂库 | 已知活性化合物库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$38.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
|
|
$0.00/1KG |
VIP2Y
|
Wuhan Haorong Biotechnology Co.,Ltd
|
2023-08-07 |
|
|
$380.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-16 |
United States