Anastrozole NEW

Product Name: Anastrozole

Brand Name: Arimidex

CAS Number: 120511-73-1

Molecular Formula: C₁₇H₁₉N₅

Molecular Weight: 293.37 g/mol

Appearance: White to off-white solid

Description:Anastrozole is a potent and selective third-generation aromatase inhibitor. It works by reducing the amount of estrogen the body produces, which can help slow or reverse the growth of certain breast cancers that require estrogen to grow.

Mechanism of Action:Anastrozole inhibits the enzyme aromatase, which is responsible for the conversion of androgens to estrogens in postmenopausal women. By inhibiting this enzyme, Anastrozole significantly lowers circulating estrogen levels, depriving the tumor of this growth-promoting hormone.

Pharmacological Properties:

• Aromatase Inhibition: Highly effective in inhibiting the aromatase enzyme.

• Breast Cancer Treatment: Indicated for the treatment of early-stage and advanced breast cancer in postmenopausal women with hormone receptor-positive tumors.

Clinical Uses:

• Adjuvant Treatment: Used after surgery to reduce the risk of breast cancer recurrence.

• First-Line Therapy: For postmenopausal women with locally advanced or metastatic breast cancer.

• Second-Line Therapy: For those with disease progression following treatment with tamoxifen.

Pharmaceutical Applications:

• Formulations: Commonly available as oral tablets for once-daily dosing.

Safety and Precautions:

• Contraindications: Not recommended for use in premenopausal women or men.

• Warnings: May decrease blood flow to the heart; caution is advised in patients with a history of coronary artery disease.

• Pregnancy and Lactation: Not to be used during pregnancy or breastfeeding.

Pharmacokinetics:

• Absorption: Rapidly absorbed after oral administration.

• Distribution: Low plasma protein binding.

• Metabolism: Extensively metabolized in the liver.

• Excretion: Primarily eliminated in the feces, with a smaller portion in urine.

Storage Conditions:

• Storage: Store in airtight containers, protected from light, and at room temperature.

Packaging:

• Packaging Options: Available in blister packs, bottles, or bulk for pharmaceutical manufacturers.

Manufacturing and Quality Control:

• Quality Assurance: Manufactured under Good Manufacturing Practices (GMP) and complies with relevant pharmacopoeial standards.

Environmental Considerations:

• Disposal: Dispose of in accordance with local regulations to minimize environmental impact.