Apigenin NEW

Apigenin is a bioflavonoid compound that can be found in a variety of plants and herbs. Chamomile tea is very abundant in it and has an anxiety-reducing effect when taken in high doses. At higher doses, it can be a sedative.

Plant origin

Apigenin is a naturally occurring flavonoid, which exists in a variety of plants in the form of plant yellow pigment, mainly from the umbelliferaceae plant, and other plants such as chamomile, bee flower, Perilla, verbena, yarrow also found its presence. Chamomile is native to the United Kingdom and is grown in Germany, France and Morocco. The Roman chamomile shares many characteristics with the German chamomile: it is about 30 cm tall, has a yellow center, white flowers, and slightly hairy leaves. Chamomile is a sleep aid, relieving inflammation and pain symptoms in patients, and relieving insomnia caused by nervous skin itching. It is also cultivated in large quantities in China for medicinal purposes and tea making. The ingredients in the daily sale of herbal tea contain apigenin, mainly from the mother chrysanthemum chamomile dried flowers.

Biological activity and pharmacological action

The molecular structure of apigenin determines its unique physiological effects and biological characteristics, and has a good biological function. A large number of studies at home and abroad have found that apigenin is a natural antioxidant, which has the effects of lowering blood pressure, dilating blood vessels, preventing atherosclerosis and inhibiting tumors. Compared with other flavonoids (quercetin, chennaetin), it has the characteristics of low toxicity and no mutagenicity. At present, apigenin has certain applications in medicine, food and other industries. However, due to the poor water solubility and intestinal absorption of apigenin, its oral bioavailability is low, and its activity in vivo is low, which limits its application to some extent.

Application:

1 flavonoid, which can capture the G2/M phase of the cell cycle and inhibit cell expansion. Inhibit growth, induce apoptosis, used in cancer drugs.

2 The flavonoid contained in apigenin is a plant flavonoid that has been found to inhibit cell proliferation by blocking the cell cycle during the G2/M phase. Inhibition of growth through cell cycle arrest and induced apoptosis appears to be related to the induction of p53. Pma-mediated tumor promotion is inhibited by inhibition of protein kinase C and the resulting inhibition of oncogene expression. The inhibition of topoisomerase catalyzed deoxyribonucleic acid reconnection and enhanced intercellular communication of gap junction were also reported.