Arotinolol hydrochloride NEW
| Price | $48 | $108 | $162 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Arotinolol hydrochloride | CAS No.: 68377-91-3 |
| Purity: 99.84% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名称 | Arotinolol hydrochloride |
| 描述 | Arotinolol hydrochloride（Arotinolol HCl） is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol hydrochloride is an antihypertensive and anti-obesity agent that improves aortic stiffness in rats and is used to study obesity-related diseases. |
| 体外活性 | Arotinolol HCl shows its potency for inhibiting the binding of the same radioligand to the 5HT1B-serotonergic receptor site, Arotinolol HCl displaces 125I-ICYP binding to 5HT1B-receptors with the pKi values of 7.97 and 8.16 respectively for β1 and β2 adrenergic receptors.[3] Arotinolol HCl shows its selectivity of β-adrenergic receptors, the result of Arotinolol HCl for β1 and β2 adrenoceptors in 125I-ICYP binding to rat cerebral cortical membranes with pKi value of 9.74 and 9.26 respectively. The selective of β1 and β2 is equal.[3] |
| 体内活性 | Arotinolol HCl (200 mg/kg; oral gavage; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mice.[3] |
| 存储条件 | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (134.8 mM) |
| 关键字 | Arotinolol Hydrochloride |
| 相关产品 | Alverine citrate | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Octopamine hydrochloride | Dexmedetomidine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Cinchonidine |
| 相关库 | FDA上市及药典收录分子库 | 经典已知活性库 | 疼痛相关化合物库 | 上市药物库 | 膜蛋白靶向化合物库 | 药物功能重定位化合物库 | 已知活性化合物库 | GPCR靶点分子库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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