ARRY 520 hydrochloride NEW
Price | $54 | $118 | $178 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-01 |
Product Details
Product Name: ARRY 520 hydrochloride | CAS No.: 1385020-40-5 |
Purity: 99.26% | Supply Ability: 10g |
Release date: 2024/11/01 |
Product Introduction
Bioactivity
名称 | ARRY 520 hydrochloride |
描述 | ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity. |
体外活性 | ARRY 520 causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells[1]. ARRY 520 induces mitotic arrest in multiple cell lines and exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors[1].ARRY 520 induces apoptosis in a dose-dependent manner in HeLa cells[1]. ARRY 520 potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway and has potential to eradicate AML progenitor cells[2]. ARRY 520 is able to induce caspase-2 activation[3]. ARRY 520 is cytotoxic in Type II EOC cells[3]. |
体内活性 | ARRY 520 has anti-tumor activitiy in vivo. ARRY 520 induced a decrease in tumor kinetics in a dose-dependent manner in female nude mice, EOC mice xenograft model[3]. |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 50 mg/mL (109.42 mM) |
关键字 | ARRY 520 Hydrochloride | ARRY-520 Hydrochloride | ARRY 520 hydrochloride | ARRY520 Hydrochloride |
相关产品 | Ispinesib | SB-743921 hydrochloride | Filanesib |
相关库 | 经典已知活性库 | ReFRAME 相关化合物库 | 抗癌临床化合物库 | 药物功能重定位化合物库 | 抑制剂库 | 临床期小分子药物库 | 已知活性化合物库 | 细胞周期化合物库 | 抗癌活性化合物库 | 抗癌药物库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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