Product Details
| Product Name:
As-358 |
CAS No.:
2222042-47-7 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | As-358 |
| Description | As-358 exhibits inhibitory effects against the Ebola virus (IC50 = 47.5 μM) and the Marburg virus (IC50 = 3.7 μM) [1]. |
| In vitro | As-358 (compound 3b), at concentrations ranging from 0-500 μM over a 10-day period, demonstrates inhibitory effects on EBOV and MARV, as evidenced by tests conducted on the Vero cell line infected with these viruses. Moreover, within a 48-hour timeframe and at lower concentrations (0-100 μM), As-358 effectively inhibits both the wild-type EboV-GP and its mutant D522A-EboV-GP, showing half-maximal inhibitory concentrations (IC 50) of 1.7 μM and 2.2 μM, respectively. The results from the Cell Proliferation Assay indicate significant inhibition against EBOV and MARV, with IC 50 values recorded at 47.5 ± 8.2 μM and 3.7 ± 1.7 μM, alongside selectivity index (SI) values of 9 and 118, correspondingly. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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