Astragalus Polysacharin NEW
| Price | $31 | $42 | $62 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Astragalus Polysacharin | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Astragalus Polysacharin |
| Description | 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole, a natural product derived from Astragalus propinquus, exhibits anticancer activity and has been shown to be effective in hepatocellular carcinoma (HCC) by inhibiting the M2 polarization of tumor-associated macrophages (TAM). |
| In vitro | Astragalus polysacharin (APS) (100 μg/mL; PBMCs) induced mature DCs could stimulate the proliferation of allogeneic T lymphocytes. The proliferation index of T cells increased with an increased ratio of stimulator cells to effector cells (P < 0.05). Levels of IL-12 and IFN-gamma in the co-culture supernatant significantly increased in a time-dependent manner (P < 0.05). APS could in vitro induce DCs to mature, promote its antigen-presenting capacity, effectively activate CTLs, and enhance the anti-tumor function of the organism.[2] |
| In vivo | Astragalus polysacharin (APS) (20 mg/kg; intragastric; once daily; 10 weeks; diabetes-induced SD rats) administration decreased the rats' fasting plasma glucose (FPG) levels and body weight. APS (20 mg/kg) administration improved the cognitive performance of diabetes-induced rats in the Morris water maze test. APS (20 mg/kg) administration reduced the number of dead cells in the CA1 region of the hippocampus. Furthermore, APS (20 mg/kg) administration obviously upregulated the phosphorylation levels CREB, NMDA, and CaMK II. CONCLUSIONS These results suggest that APS has neuroprotective effects, and it may be a candidate for the treatment of neurodegenerative diseases such as diabetic cognitive impairment.[1] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 31.25 mg/mL, Sonication is recommended. DMSO : 50 mg/mL (196.32 mM) |
| Keywords | 89250-26-0 |
| Inhibitors Related | UNC2025 | Cabozantinib | Gilteritinib | Bemcentinib | SGI-7079 | Dubermatinib | Sitravatinib | NCT-503 | Cabozantinib S-malate | G-749 | AXL-IN-13 | BMS 777607 |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Tyrosine Kinase Inhibitor Library | Natural Product Library | Saccharide and Glycoside Natural Product Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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