ATR-IN-29 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: ATR-IN-29 | CAS No.: 2761193-67-1 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | ATR-IN-29 |
| Description | ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1]. |
| In vitro | ATR-IN-29 (compound 1) exhibited antiproliferative activity over 4 days, with IC50 values of 156.70, 38.81, 22.48, 181.60, and 19.02 nM against A549, HCC1806, HCT116, OVCAR-3, and NCI-H460 cell lines, respectively [1]. |
| In vivo | ATR-IN-29 administered at a dose of 10 mg/kg orally once demonstrated favorable pharmacokinetic parameters in CD-1 (ICR) mice, with a half-life (t1/2) of 1.64 hours, a maximum concentration (Cmax) of 9343 ng/mL, and an area under the curve from time zero to the last measurable concentration (AUC 0-t) of 98507 ng·h/mL, as well as an area under the curve from time zero to infinity (AUC 0-inf) of 98517 ng·h/mL. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | CP-466722 | Ro 90-7501 | Dactolisib | Berzosertib | Elimusertib | GJ103 sodium salt | KU60019 | Ceralasertib | (Z)-Mirin | NU6027 | Schisandrin B | AZ32 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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| $50.00/5mg |
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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