Benzeneacetic acid, alpha-(hydroxymethyl)-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

Chemical & Physical Properties:

 

Detail:

Name: Benzeneacetic acid, alpha-(hydroxymethyl)-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Synonyms: 1aH,5aH-Tropan-3a-ol ( à)-tropate (ester) (8CI);Benzeneacetic acid, a-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-;Atropin;Tropine tropate;dl-Hyoscyamine;
CAS Registry number: 51-55-8
EINECS:200-104-8
Molecular Formula: C17H23NO3
Boiling Point: 429.8 ºC at 760 mmHg
Flash Point: 213.7 ºC
Density: 1.19 g/cm3
Water:H2O: 2 mg/mL
Appearance: powder
Safety Statements: 25-45-36-26 
Transport:1544

 

Description
 

Atropine is an alkaloid extracted from the Atropa bell-adonna, Datura stramonium, or Hyosc-yamus niger. What is naturally occurring is the unstable L-hyoscyamine, which can be converted to the stable racemate atropine after chemical treatment. It can also be chemically synthesized; what is commonly used in its sulfate. It appears as white crystalline powder, being odorless, bitter, and soluble in water and alcohol. Upon contact with alkaline drugs, it can cause decomposition. Atropine blocks the M-choline receptor, thereby antagonizing the M-like effect of acetylcholine or its quasi-drug (muscarinic effect).
The main effect is as follows:

1. Relax the smooth muscle: This product has the role of relaxation of many visceral smooth muscle; it has remarkable relaxation effect on over-activity or spammed smooth muscle, while having less effect on the normal activity of the smooth muscle.

2. Inhibition of glandular secretion: inhibit the glandular secretion by blocking the M-choline receptor. The most obvious effect occurs on salivary glands and sweat glands. It can also greatly reduce the secretion of lacrimal glands and respiratory glands, but the impact on gastric acid secretion is smaller.

3. The effect on the eye: atropine, through blocking the pupil sphincter and ciliary muscle M-choline receptors, is manifested as mydriasis, increased intraocular pressure and adjust paralysis. All three effects have important clinical implications.

4. The effect on the cardiovascular: a larger dose (1 ~ 2mg) atropine can get rid of the inhibitory effect of the vagus nerve on the heart, thus accelerating the heart rate. Large doses can dilate the skin and visceral blood vessels, and relieve arteriolar spasm. Its mechanism of dilating blood vessels and relieving small vasospasm is unknown.

5. Excitement of the central nervous system: high-dose cause irritability, prolonged talk and delirium. Poisoning dose (more than 10mg) can produce hallucinations, disorientation, involuntary exercise and convulsions.

Atropine Basic Information CAS No. 51-55-8:

 

 

Atropine Chemical Properties CAS No.51-55-8:

 

Usage: 

anticholinergic, mydriatic

 

 

 

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