Product Details
| Product Name:
BTB09089 |
CAS No.:
245728-44-3 |
| Purity:
100% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | BTB09089 |
| Description | BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages. |
| In vitro | BTB09089 (0-18 μM; 30 min) significantly increases cAMP accumulation in HEK293 cells expressing hTDAG8 and mTDAG8, but not in control HEK293 cells. It does not enhance cAMP accumulation in HEK293 cells expressing hGPR4 or inositol phosphate accumulation in HEK293 cells expressing hOGR1.[1] BTB09089 (0-18 μM; 30 min) enhances cAMP accumulation dose-dependently at pH 7.0-7.9, but not at pH 6.5.[1] BTB09089 (1-5 μM; 20 h) inhibits IL-2 production in WT mouse splenocytes dose-dependently, without affecting IL-2 production in TDAG8 KO mice or cell viability.[1] BTB09089 (1-5 μM; 18 h) inhibits TNF-α and IL-6 production stimulated by LPS while enhancing IL-10 production in TG-PEC induced by LPS stimulation with sulfated ester.[1] |
| In vivo | BTB09089 (5-20 μM, 8 μL; i.c.v.; administered 6 hours prior to MCAO) reduces cerebral ischemia-reperfusion injury in rats.[2] |
| Storage | Shipping with blue ice. |
| Solubility Information | DMSO : 3.87 mg/mL (10 mM)
|
| Keywords | BTB09089 | BTB 09089 | GPR65 agonist | BTB-09089 |
| Inhibitors Related | Vincamine | Norharmane | Cyclophosphamide hydrate | Monomethyl fumarate | Questiomycin A | CRTh2 antagonist 2 | Methoxsalen | Benzyl nicotinate | 1-methoxycyclopropanecarboxylic acid | TUG-1375 | Cyclophosphamide | Crystal Violet |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Membrane Protein-targeted Compound Library | Anti-Aging Compound Library | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States