Carboxyethylgermanium sesquioxide NEW

• MOLECULAR FORMULA :

• C6-H10-Ge2-O7

• MOLECULAR WEIGHT :

• 339.34

• WISWESSER LINE NOTATION :

• QV2-GE-O&O-GE-O&2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 7050 mg/kg

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 1670 mg/kg

• TOXIC EFFECTS :

• Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - hypermotility, diarrhea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• >4 gm/kg

• TOXIC EFFECTS :

• Skin and Appendages - dermatitis, other (after systemic exposure)

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• >200 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 5600 mg/kg

• TOXIC EFFECTS :

• Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 1250 mg/kg

• TOXIC EFFECTS :

• Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Skin and Appendages - hair

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• >4 gm/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• >200 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD - Lethal dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Mammal - dog

• DOSE/DURATION :

• >4 gm/kg

• TOXIC EFFECTS :

• Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 7200 mg/kg/90D-I

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - changes in lung weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in leukocyte (WBC) count

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 274 gm/kg/1Y-I

• TOXIC EFFECTS :

• Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Related to Chronic Data - death

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Mammal - dog

• DOSE/DURATION :

• 72800 mg/kg/13W-I

• TOXIC EFFECTS :

• Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 292 gm/kg/1Y-I

• TOXIC EFFECTS :

• Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 11 gm/kg

• SEX/DURATION :

• female 7-17 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility Reproductive - Specific Developmental Abnormalities - musculoskeletal system

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 44 gm/kg

• SEX/DURATION :

• female 7-17 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Newborn - sex ratio

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 78 gm/kg

• SEX/DURATION :

• female 17 day(s) after conception - 21 day(s) post-birth

• TOXIC EFFECTS :

• Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - delayed effects

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• DOSE :

• 94 gm/kg

• SEX/DURATION :

• male 90 ? pre-mating female 90 day(s) pre-mating - 7 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Newborn - physical

• TYPE OF TEST :

• Micronucleus test

MUTATION DATA

• TYPE OF TEST :

• Cytogenetic analysis

• TEST SYSTEM :

• Rodent - hamster Lung

• DOSE/DURATION :

• 20 gm/kg

• REFERENCE :

• KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,289,1990