Product Details
| Product Name:
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate |
CAS No.:
132465-11-3 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate |
| Description | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), a potent inhibitor of 12/15-Lipoxygenases (LO), shows potential in type 1 diabetes mellitus research [1]. |
| In vitro | High glucose or 12(S)-HETE significantly enhanced transendothelial dextran transport, an effect amplified when both were combined. The 12/15-LO inhibitor, CDC, partially reduced this enhanced dextran transport [1]. |
| In vivo | Elevated glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) levels can modify phosphorylation levels of vascular endothelial (VE)-cadherin and β‐catenin without affecting their total protein expression. Conversely, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), counteracts the impact of high glucose on protein phosphorylation, thereby preserving the integrity of the endothelial cell barrier. These findings were substantiated by a mouse diabetes mellitus model [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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