Creatinine

Use and synthesis method of creatinine Chemical properties White crystal. It decomposes when heated to 300 ℃, and is soluble in water, slightly soluble in alcohol, and almost insoluble in ether, acetone and chloroform. Purpose Analytical reagent (blood identification), biochemical research reagent. Purpose: It is used to treat acute and chronic hepatitis, cirrhosis, jaundice and general liver disorders. Purpose Health care products; Biochemical reagent; Analysis reagent (blood identification), test renal function. Purpose Blood identification and analysis reagents and health care products are used as intermediates of auxiliary drugs for liver diseases. The production method is obtained from the salt formation of methyl dichloroacetate or dichloroacetic acid and diisopropylamine. Add methyl dichloroacetate into water, add diisopropylamine slowly after stirring and cooling, and control the temperature below 6Chemicalbook 0 ℃. White precipitates are precipitated, and the test pH should be above 7, otherwise add a proper amount of diisopropylamine. Stir and cool for 24 hours to make the crystal complete, filter, wash the crystal with cold ethanol, and dry it at 70 ℃ to obtain diisopropylamine dichloroacetate. Concentrate the mother liquor, recover the crude product, and recrystallize it with ethanol to obtain the finished product. Production method: heat 900g of creatine hydrate, 550ml of concentrated hydrochloric acid and 150ml of water for 24h. Hot filtration, the filtrate is cooled to 0-5 ℃ in the ice bath, and 1L28% ammonia is added. Stir under cooling to reduce the temperature to 0 ℃, filter out the creatinine crystal, wash it with ammonia until it contains no chloride ions, then wash it with cold methanol, and dry it to obtain about 550g of creatinine.