Product Details
| Product Name:
CU-115 |
CAS No.:
2471982-20-2 |
| Purity:
100% |
Supply Ability:
10g |
| Release date:
2024/11/11 |
Product Introduction
Bioactivity
| 名称 | CU-115 |
| 描述 | CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells. |
| 体外活性 | CU-115 (1, 5, and 20 µM) inhibits TLR9 to 10-25% inhibition. CU-115 (5-20 µM) inhibits increases in the activity of type I IFN transcriptional induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD. CU-115 (5-20 µM) abolishes the TNF-α production activated by R848 (1 µg/ml) and represses the expression of IL-1β in hTHP-1 cells. CU-115 does not modulate the NF-kB inhibition induced by Pam2CSK4, Pam3CSK4, LPS, R848, Poly(I:C), and Flic in HEK-293 TLR1/2, TLR2/6, TLR3, and TLR4 cells[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (79.06 mM), Sonication is recommended.
|
| 关键字 | CU-115 | CU115 | CU 115 |
| 相关产品 | Polyinosinic-polycytidylic acid sodium | CU-CPD107 | Imiquimod hydrochloride | Hydroxychloroquine | Chloroquine phosphate | Hydroxychloroquine sulfate | Chloranil | Chloroquine | Imiquimod | TLR3-IN-1 | Rabeximod | Resiquimod |
| 相关库 | 经典已知活性库 | 膜蛋白靶向化合物库 | 抑制剂库 | 已知活性化合物库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$30.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-11 |
|
|
$55.00/1box |
VIP1Y
|
hebei hongtan Biotechnology Co., Ltd
|
2024-03-14 |
|
|
$10.00/1mG |
VIP1Y
|
CONTIDE BIOTECH CO.,LTD
|
2024-05-14 |
United States