Dapoxetine hydrochloride
| Price | $10 |
| Package | 1kg |
| Min. Order: | 10kg |
| Supply Ability: | 20T |
| Update Time: | 2022-11-04 |
Product Details
| Product Name: Dapoxetine hydrochloride | CAS No.: 129938-20-1 |
| EC-No.: 640-411-8 | Min. Order: 10kg |
| Purity: 99 | Supply Ability: 20T |
| Release date: 2022/11/04 |
Name: Lemon
Whats-app/ Telegram: +86 17331136691
Wick-r: llemonnn
Wechat ID : 17331136691
lemon@hbyinsheng.com
| Description | PE
is the most common form of male sexual dysfunction affecting 20-40% of
men globally at some point in their lives. Ejaculation is a reflex
comprising different sensory pathways, motor centers, and nerve
pathways. This ejaculatory reflex has been shown to be controlled
primarily by serotonin and dopamine. Dapoxetine is a short-acting SSRI.
It is differentiated from the existing SSRI treatments for PE by the
fact that it can be administered on an as-needed basis. In healthy
subjects, dapoxetine is rapidly absorbed after oral administration with a
peak plasma concentration (Tmax) occurring between 1.4 and 2 h. Dapoxetine also showed statistically significant improvements in perceived control over ejaculation, PE-related personal distress, and other patient-reported outcomes in all five trials. Dapoxetine treatment was generally well tolerated, with low incidences of discontinuation syndrome, sexual dysfunction, and treatment-emergent mood symptoms. The most common adverse events with dapoxetine included nausea, diarrhea, headache, dizziness, and somnolence. |
| Chemical Properties | Off-white Cryst |
| Originator | Lilly (US) |
| Uses | Selective serotonin reuptake inhibitor (SSRI) |
| Uses | Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men. D |
| Uses | A selective serotonin reuptake inhibitor |
| Brand name | Priligy |
| Chemical Synthesis | Dapoxetine can be synthesized in four chemical steps starting from R-1phenyl- 1,3-propanediol via selective tosylation of the primary hydroxy group with p-toluenesulfonyl chloride, triethylamine and 4-(dimethylamino) pyridine (DMAP), and subsequent condensation with 1naphthol by means of sodium- or lithium hydroxide to yield R-3-(1naphthyloxy)- 1-phenylpropanol as the key intermediate. Conversion of the alcohol group to the corresponding mesylate with methanesulfonyl chloride, triethylamine, and DMAP, followed by treatment with dimethylamine affords dapoxetine, which is then acidified to its hydrochloride salt. |
Company Profile Introduction
Hebei Yinsheng Technology Co., Ltd is a company dedicated to the research and development, production and sales of organic compounds, pharmaceutical intermediates and chemical raw materials. The company has a long-term partnership with Chemical Industry Research Institute and its universities. It is a research and development enterprise of new pharmaceutical and chemical materials oriented to the global pharmaceutical market demand. Continuously innovate the world's leading new chemical and pharmaceutical products. It integrates the research and development, industrialization and market operation of innovative drugs. The company has strong technical strength, advanced equipment, strict quality management system and high-quality after-sales service. Over the years, our products have been widely sold to many countries and regions, and we have established stable cooperative relationships with traders and end users all over the world. We look forward to cooperating with you
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China- Since: 2020-11-03
- Address: Room 1908, Building 6, Lucheng Business Center Shijiazhuang Hebei China
INQUIRY
陶欣月
+86-17331136691
lemon@hbyinsheng.com
+86-17331136691
lemon@hbyinsheng.com