Desmopressin acetate
| Price | $1 |
| Package | 1piece |
| Min. Order: | 1piece |
| Supply Ability: | 1000 |
| Update Time: | 2025-04-16 |
Product Details
| Product Name: Desmopressin acetate | CAS No.: 16789-98-3 |
| Min. Order: 1piece | Purity: 99% |
| Supply Ability: 1000 | Release date: 2025/04/16 |
Chemical Name:Desmopressin acetate
Molecular Formula:C<sub>46</sub>H<sub>64</sub>N<sub>14</sub>O<sub>12</sub>S<sub>2</sub>·C<sub>2</sub>H<sub>4</sub>O<sub>2</sub>
CAS:16789-98-3
Molecular Weight:1129.34 g/mol (free base: 1069.24 g/mol)
Appearance:White or almost white powder
Solubility:Freely soluble in water; slightly soluble in ethanol
Stability:Stable at 2–8°C; protect from light and moisture
Mode of Action:Synthetic analog of vasopressin; binds to V<sub>2</sub> receptors to reduce urine output and increase clotting factor VIII.
Pharmacological Use:Treatment of diabetes insipidus, nocturnal enuresis, and hemophilia A/von Willebrand disease (Type I).
Half-life:1.5–2.5 hours (prolonged compared to vasopressin)
Excretion:Primarily renal (unchanged)
Origin:Synthetic peptide (modified vasopressin structure).
Desmopressin acetate is a synthetic peptide hormone analog of vasopressin, designed to enhance antidiuretic effects while minimizing vasopressor activity. It is clinically used for:
| Test Parameter | Specification | Test Method | Reference Standard |
|---|---|---|---|
| Appearance | White or almost white powder | Visual inspection | EP/USP |
| Identification | Complies (HPLC/MS or FTIR) | HPLC/MS or FTIR | EP/USP |
| Assay (HPLC Purity) | 97.0%~103.0% (anhydrous basis) | RP-HPLC (C18 column) | EP/USP |
| Related Substances | Total impurities ≤ 3.0% Any single impurity ≤ 1.5% | HPLC (gradient elution) | ICH Q3A/B |
| Water Content | ≤ 8.0% (Karl Fischer) | Karl Fischer titration | EP/USP <921> |
| Acetic Acid Content | 5.0%~8.0% (w/w) | Titration/GC | EP |
| Acetate Content | 5.0%~8.0% | Ion chromatography | EP |
| Heavy Metals | ≤ 20 ppm | ICP-MS/USP <231> | EP/USP |
| Microbial Limits | TAMC ≤ 100 CFU/g TYMC ≤ 50 CFU/g Absence of specified pathogens | Microbial enumeration | EP/USP <61>, <62> |
| Endotoxin | < 50 IU/mg | LAL test | EP/USP <85> |
| pH (1% solution) | 3.5~5.5 | Potentiometric method | EP/USP <791> |
| Specific Rotation | -70° to -80° (c=1 in water) | Polarimetry | EP/USP <781> |
| Peptide Content | ≥ 90.0% (by amino acid analysis) | Amino Acid Analysis (AAA) | EP |
| Biological Activity | 90%~115% of stated potency | In vitro bioassay (V2 receptor activity) | EP/USP |
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