Product Description

Appearance and properties: transparent liquid

Density: 1.080 g/mL at 20 °C(lit.)

Boiling point: 279-283 °C(lit.)

Melting point: -33°C

Flash point: 311 °F

Refractive index: n20/D 1.463

Water solubility: insoluble

Stability: Stable under normal temperatures and pressures.

Storage conditions: Store in a cool, dry place. Keep container closed when not in use.

Production method

The mixture of triethyl orthoformate, acetic anhydride, diethyl malonate and anhydrous zinc oxide was stirred and heated, and kept at 102-115℃ for 2.5h, at 115-127℃ for 7h, then added some acetic anhydride and triethyl orthoformate, and continued to heat up to 127-145℃ and 145-155℃ for 2h. The reactants are then cooled to room temperature and filtered. The filtrate was distilled under vacuum, and the fraction of 108-110℃(33Pa) was collected to obtain the finished product with a yield of 50-60%.

Purpose of use

This product is an important organic raw material containing a variety of active groups in the molecule, which can be polycondensation and cyclization condensation with a variety of substances, and is mainly used in the synthesis of floxacin.

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