Dihexa NEW
| Price | Get Latest Price | ||
| Package | 1KG | 5KG | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 20 T each week |
| Update Time: | 2023-08-16 |
Product Details
| Product Name: Dihexa | CAS No.: 1401708-83-5 |
| EC-No.: 227-005-2 | Min. Order: 1KG |
| Purity: 98%~99% | Supply Ability: 20 T each week |
| Release date: 2023/08/16 |
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| Product Name: | Dihexa |
| Synonyms: | Dihexa;Hexanoyl-Tyr-Ile-Ahx-NH2;N-hexanoic-Try-Ile-(6)-amino hexanoic amide;PNB-0408;Dihexa (PNB-0408);N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-L-ISOLEUCINAMIDE;L-Isoleucinamide, N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;TIANFUCHEM--1401708-83-5---Dihexa |
| CAS: | 1401708-83-5 |
| MF: | C27H44N4O5 |
| MW: | 504.66 |
| EINECS: | 227-005-2 |
| Product Categories: | 1401708-83-5 |
| Mol File: | 1401708-83-5.mol |
 | |
| Dihexa Chemical Properties |
| Melting point | >209°C (dec.) |
| Boiling point | 866.2±65.0 °C(Predicted) |
| density | 1.111±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.83±0.15(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChIKey | ADWKPLXLPNPJTR-JTJYXVOQSA-N |
| SMILES | C(N)(=O)[C@H]([C@@H](C)CC)N(C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)CCCCC)CCCCCC(N)=O |
| Dihexa Usage And Synthesis |
| Description | Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor. |
| Uses | N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent. |
| Uses | Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease. |
| benefits | As a new drug, Dihexa has been highly seen to help people experiencing Alzheimer's Disease. Thus, it's main function is to relieve and supplement people who are stricken by this Disease to slow down the progression of Alzheimer's. The best thing about Dihexa is its ability to be able to repair damages found in the synapse that is just between the neurons. Here are some of the benefits of Dihexa: Helps people having Alzheimer's Disease and those with Parkinson's Disease Can increase your mental stamina Can improve creative thinking skills Can enhance conversational skills Can improve one's ability to solve problems Can help in managing depression Improves memory Dihexa also helps one improve focus and learning. That's why this is good most, especially for people who study too. It can even improve heart health, and also boost medical endurance. People who use Dihexa have had testimonies of how this peptide has helped improve their creativity, thinking, and even problem-solving skills. Although you must keep in mind that despite the benefits of Dihexa, it still has some side effects that you must be aware of primarily when it is being regularly used. One who even stops using Dihexa can have severe withdrawal effects once they decide to discontinue using this peptide. Some side effects could be unexpected jitters or even irritability. |
| Biological Activity | Dihexa is an orally active, blood-brain barrier-permeable angiotensin IV analog; exhibits high affinity binding hepatocyte growth factor (HGF) with a Kd of 65 pM. Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met. Dihexa has a long circulating half-life. Dihexa exhibits procognitive activity. Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons. |
| Clinical Use | Dihexa is a peptide variant derived from angiotensin IV which has been found to potently improve cognitive function in animal models of disease such as Alzheimer’s. Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and has been shown to enhance acquisition, consolidation, and recall of learning and memory in animal models when administered centrally or peripherally. In an essay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than BDNF. It could possibly help in the repair of the brain and nerves in neurological disease. |
| Mode of action | Being a first-class compound that is orally active, Dihexa works through penetrating the blood-brain barriers. This also works through facilitating one's memory consolidation and even memory retrieval. Researchers have seen how this peptide is very active. It also shows a very promising characteristic in terms of overcoming any memory and motor dysfunction. |
| Toxicity evaluation | According to a patent, "Short duration safety studies with Dihexa have uncovered no apparent toxicity. Of particular note is a lack of neoplastic induction, since c-Met is recognized as an oncogene. This is unsurprising since oncogenesis requires multiple mutations including both oncogene induction and tumor suppressor attenuation." |
Company Profile Introduction
Shandong Huisheng Import & Export Co., Ltd. is located in Jinan city, Shandong Province, is a collection of domestic trade, international trade in one of the diversified services company. Our goal is to provide customers with high quality solutions and one-stop purchasing experience. At present, the company business scope involves five areas: Organic chemical raw materials, inorganic chemical raw materials, fine chemical raw materials, dangerous chemicals and green environmental protection chemical technology project promotion, and we has also established good relations of cooperation with several well-known enterprises and won the strong support of extensive trust from the new and old customers.
Products are widely used in automobile, household appliances, office supplies, mobile phone accessories, routers, food, medical and other fields. At present, our business covers 30 countries, and our customers mainly come from Australia, New Zealand, Canada, Germany, France, Poland, South Korea, Russia, Bangladesh, Vietnam, Kazakhstan, India, Ghana, Nigeria, South Africa, Egypt and other more than 30 countries.
The company has a sound quality management system and advanced professional equipment, with a positive attitude to meet the changing needs of customers. We take "quality products, quality service, competitive price, timely delivery" as the purpose, looking forward to greater cooperation with overseas customers on the basis of mutual benefit.
Our company provides a wide range of products to meet your various needs. Since its inception, the company has always adhered to the "quality first, customer first, reputation first" business policy, wholeheartedly meet the potential needs of our customers. Under the irresistible situation of economic globalization, our company is willing to cooperate sincerely with enterprises around the world to achieve a win-win situation.
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China- Since: 2020-11-16
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